Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein

• Published in: Nature medicine Vol. 17; no. 2; pp. 206 - 210
• Main Authors: Liu, Jia, Gao, Ben-Bo, Clermont, Allen C, Blair, Price, Chilcote, Tamie J, Sinha, Sukanto, Flaumenhaft, Robert, Feener, Edward P
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.02.2011; Nature Publishing Group
• Subjects: 631/250/232/2051/1339; 631/80/470/2284; 692/699/317; 692/699/375/1370/534; Animals; Biomedical and Life Sciences; Biomedicine; Blood; Blood platelets; Blood-Brain Barrier - physiopathology; Brain; Brain - drug effects; Brain - physiopathology; Cancer Research; Cerebral Hemorrhage - physiopathology; Complications and side effects; Diabetes Mellitus, Experimental - physiopathology; Diagnosis; Glucose; Glycoproteins; Hematoma - physiopathology; Hemorrhage; Hyperglycemia; Hyperglycemia - physiopathology; Infectious Diseases; Inhibition; Injection; Injections, Intraventricular; Intracerebral hemorrhage; Kallikrein; letter; Metabolic Diseases; Mice; Mice, Inbred C57BL; Molecular Medicine; Neurosciences; Physiological aspects; Plasma; Plasma Kallikrein - pharmacology; Plasma Kallikrein - physiology; Plasminogen - physiology; Platelet Aggregation - drug effects; Platelet Aggregation - physiology; Rats; Rats, Sprague-Dawley; Risk factors; United States

Intracerebral hemorrhage, a common cause of stroke, has more dire consequences in diabetics than in nondiabetics. Using experimental rodent models, Jia Liu et al . find that the deleterious effects of diabetes on intracerebral hemorrhage may be due to the action of the protein plasma kallikrein, dis...