Molecular mimicry by an F-box effector of Legionella pneumophila hijacks a conserved polyubiquitination machinery within macrophages and protozoa

• Published in: PLoS pathogens Vol. 5; no. 12; p. e1000704
• Main Authors: Price, Christopher T, Al-Khodor, Souhaila, Al-Quadan, Tasneem, Santic, Marina, Habyarimana, Fabien, Kalia, Awdhesh, Kwaik, Yousef Abu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.12.2009; Public Library of Science (PLoS)
• Subjects: Acanthamoeba; Acanthamoeba - metabolism; Acanthamoeba - parasitology; Animals; Ankyrins - metabolism; Bacterial Proteins - metabolism; Bacteriology; Dictyostelium - metabolism; Dictyostelium - parasitology; Dictyostelium discoideum; Genetic aspects; Humans; Immune response; Immunoprecipitation; Legionella pneumophila; Legionella pneumophila - metabolism; Legionella pneumophila - pathogenicity; Legionnaires disease; Legionnaires' Disease - metabolism; Macrophages; Macrophages - metabolism; Macrophages - parasitology; Mice; Microbiology; Microbiology/Cellular Microbiology and Pathogenesis; Microscopy, Confocal; Molecular evolution; Molecular Mimicry - immunology; Physiological aspects; Protein Transport - physiology; Proteins; Transfection; Ubiquitination; United States

The ability of Legionella pneumophila to proliferate within various protozoa in the aquatic environment and in macrophages indicates a remarkable evolution and microbial exploitation of evolutionarily conserved eukaryotic processes. Ankyrin B (AnkB) of L. pneumophila is a non-canonical F-box-contain...