HLA-E-restricted cross-recognition of allogeneic endothelial cells by CMV-associated CD8 T cells: a potential risk factor following transplantation

• Published in: PloS one Vol. 7; no. 11; p. e50951
• Main Authors: Allard, Mathilde, Tonnerre, Pierre, Nedellec, Steven, Oger, Romain, Morice, Alexis, Guilloux, Yannick, Houssaint, Elisabeth, Charreau, Béatrice, Gervois, Nadine
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 30.11.2012; Public Library of Science (PLoS)
• Subjects: Antigens; Arteries - pathology; B cells; Binding sites; Biology; CD8 antigen; CD8-Positive T-Lymphocytes - drug effects; CD8-Positive T-Lymphocytes - immunology; Cell Separation; Cross Reactions - drug effects; Cross Reactions - immunology; Cytomegalovirus; Cytomegalovirus - drug effects; Cytomegalovirus - immunology; Cytomegalovirus infections; Cytomegalovirus Infections - immunology; Endothelial cells; Endothelial Cells - drug effects; Endothelial Cells - immunology; Endothelial Cells - pathology; Endothelium; Graft rejection; Health aspects; Histocompatibility antigen HLA; HLA antigens; HLA Antigens - immunology; Humans; Immunology; Infection; Infections; Interferon-gamma - pharmacology; Kidney Transplantation; Life Sciences; Ligands; Lymphocytes; Lymphocytes T; Medicine; Organs; Patients; Peptides; Phenotype; Potassium channels (inwardly-rectifying); Protein Sorting Signals; Receptors; Receptors, Antigen, T-Cell - immunology; Receptors, Natural Killer Cell - immunology; Recognition; Rejection; Risk Factors; T cell receptors; T cells; T-cell receptor; Transplantation; Transplantation, Homologous; Transplants & implants; France

Although association between CMV infection and allograft rejection is well admitted, the precise mechanisms involved remain uncertain. Here, we report the characterization of an alloreactive HLA-E-restricted CD8 T cell population that was detected in the PBL of a kidney transplant patient after its...