The Somatostatin Analogue Octreotide Inhibits Growth of Small Intestine Neuroendocrine Tumour Cells

• Published in: PloS one Vol. 7; no. 10; p. e48411
• Main Authors: Li, Su-Chen, Martijn, Cécile, Cui, Tao, Essaghir, Ahmed, Luque, Raúl M., Demoulin, Jean-Baptiste, Castaño, Justo P., Öberg, Kjell, Giandomenico, Valeria
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.10.2012; Public Library of Science (PLoS)
• Subjects: Analysis; Annexins; Antineoplastic Agents - pharmacology; Biology; Biomarkers; Cancer therapies; Cell cycle; Cell Differentiation - drug effects; Cell growth; Cell Line, Tumor; Cell proliferation; Cell Proliferation - drug effects; Differentiation; Disease control; DNA microarrays; Gene expression; Genes; Growth; GTPase-activating protein; Guanosine triphosphatases; Hospitals; Humans; Immunology; Intestinal Neoplasms - pathology; Intestine, Small - pathology; Laboratories; Medicine; Membrane proteins; Metastasis; Molecular modelling; Neoplasm Staging; Nets; Neuroendocrine tumors; Neuroendocrine Tumors - pathology; Octreotide; Octreotide - pharmacology; Oncology; Paraffin; Physiology; Proteins; Receptors; Receptors, Somatostatin - genetics; RNA, Messenger - genetics; RNA, Messenger - metabolism; Science; Signal Transduction - drug effects; Small intestine; Somatostatin; Somatostatin - analogs & derivatives; Somatostatin receptors; Symptom management; Tissues; Transcription; Transcription, Genetic - drug effects; Transcriptome - drug effects; Transforming growth factor-b; Transforming growth factors; Tumor necrosis factor; Tumors; Up-Regulation - drug effects; Sweden

Octreotide is a widely used synthetic somatostatin analogue that significantly improves the management of neuroendocrine tumours (NETs). Octreotide acts through somatostatin receptors (SSTRs). However, the molecular mechanisms leading to successful disease control or symptom management, especially w...