Expression of miR-142-5p in peripheral blood mononuclear cells from renal transplant patients with chronic antibody-mediated rejection

• Published in: PloS one Vol. 8; no. 4; p. e60702
• Main Authors: Danger, Richard, Paul, Chloé, Giral, Magali, Lavault, Amélie, Foucher, Yohann, Degauque, Nicolas, Pallier, Annaïck, Durand, Maxim, Castagnet, Stéphanie, Duong Van Huyen, Jean-Paul, Delahousse, Michel, Renaudin, Karine, Soulillou, Jean-Paul, Brouard, Sophie
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 05.04.2013; Public Library of Science (PLoS)
• Subjects: Analysis; Antibodies; Antibodies - immunology; Biology; Biomarkers; Biomarkers - blood; Biomarkers - metabolism; Biopsy; Blood; Blood cells; Cancer; Cell activation; Diagnosis; Gene expression; Gene Expression Regulation; Genes; Graft rejection; Graft Rejection - blood; Graft Rejection - genetics; Graft Rejection - immunology; Graft Rejection - pathology; Histology; Human health and pathology; Humans; Identification; Immunology; Kidney transplantation; Kidney Transplantation - adverse effects; Leukocytes (mononuclear); Leukocytes, Mononuclear - metabolism; Life Sciences; Lymphocytes T; Medicine; MicroRNA; MicroRNAs; MicroRNAs - blood; MicroRNAs - genetics; miRNA; Modulation; Organ transplant recipients; Overexpression; Patients; Peripheral blood mononuclear cells; Rejection; Renal failure; Renal function; Ribonucleic acid; RNA; T cells; Time Factors; Transplantation; Transplants & implants; France

In renal transplantation, the unresponsiveness of patients undergoing chronic antibody mediated rejection (CAMR) to classical treatment stress on the need for accurate biomarkers to improve its diagnosis. We aim to determine whether microRNA expression patterns may be associated with a diagnosis of...