Expression of miR-142-5p in peripheral blood mononuclear cells from renal transplant patients with chronic antibody-mediated rejection
In renal transplantation, the unresponsiveness of patients undergoing chronic antibody mediated rejection (CAMR) to classical treatment stress on the need for accurate biomarkers to improve its diagnosis. We aim to determine whether microRNA expression patterns may be associated with a diagnosis of...
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Published in | PloS one Vol. 8; no. 4; p. e60702 |
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Main Authors | , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
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Public Library of Science
05.04.2013
Public Library of Science (PLoS) |
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Abstract | In renal transplantation, the unresponsiveness of patients undergoing chronic antibody mediated rejection (CAMR) to classical treatment stress on the need for accurate biomarkers to improve its diagnosis. We aim to determine whether microRNA expression patterns may be associated with a diagnosis of CAMR. We performed expression profiling of miRNAs in peripheral blood mononuclear cells (PBMC) of kidney transplant recipients with CAMR or stable graft function. Among 257 expressed miRNAs, 10 miRNAs associated with CAMR were selected. Among them, miR-142-5p was increased in PBMC and biopsies of patients with CAMR as well as in a rodent model of CAMR. The lack of modulation of miR-142-5p in PBMC of patients with renal failure, suggests that its over-expression in CAMR was associated with immunological disorders rather than renal dysfunction. A ROC curve analysis performed on independent samples showed that miR-142-5p is a potential biomarker of CAMR allowing a very good discrimination of the patients with CAMR (AUC = 0.74; p = 0.0056). Moreover, its expression was decreased in PHA-activated blood cells and was not modulated in PBMC from patients with acute rejection, excluding a non-specific T cell activation expression. The absence of modulation of this miRNA in immunosuppressed patients suggests that its expression was not influenced by treatment. Finally, the analysis of miR-142-5p predicted targets under-expressed in CAMR PBMC in a published microarray dataset revealed an enrichment of immune-related genes. Altogether, these data suggest that miR-142-5p could be used as a biomarker in CAMR and these finding may improve our understanding of chronic rejection mechanisms. |
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AbstractList | In renal transplantation, the unresponsiveness of patients undergoing chronic antibody mediated rejection (CAMR) to classical treatment stress on the need for accurate biomarkers to improve its diagnosis. We aim to determine whether microRNA expression patterns may be associated with a diagnosis of CAMR. We performed expression profiling of miRNAs in peripheral blood mononuclear cells (PBMC) of kidney transplant recipients with CAMR or stable graft function. Among 257 expressed miRNAs, 10 miRNAs associated with CAMR were selected. Among them, miR-142-5p was increased in PBMC and biopsies of patients with CAMR as well as in a rodent model of CAMR. The lack of modulation of miR-142-5p in PBMC of patients with renal failure, suggests that its over-expression in CAMR was associated with immunological disorders rather than renal dysfunction. A ROC curve analysis performed on independent samples showed that miR-142-5p is a potential biomarker of CAMR allowing a very good discrimination of the patients with CAMR (AUC = 0.74; p = 0.0056). Moreover, its expression was decreased in PHA-activated blood cells and was not modulated in PBMC from patients with acute rejection, excluding a non-specific T cell activation expression. The absence of modulation of this miRNA in immunosuppressed patients suggests that its expression was not influenced by treatment. Finally, the analysis of miR-142-5p predicted targets under-expressed in CAMR PBMC in a published microarray dataset revealed an enrichment of immune-related genes. Altogether, these data suggest that miR-142-5p could be used as a biomarker in CAMR and these finding may improve our understanding of chronic rejection mechanisms. |
Audience | Academic |
Author | Foucher, Yohann Durand, Maxim Castagnet, Stéphanie Lavault, Amélie Duong Van Huyen, Jean-Paul Soulillou, Jean-Paul Pallier, Annaïck Delahousse, Michel Degauque, Nicolas Paul, Chloé Brouard, Sophie Renaudin, Karine Danger, Richard Giral, Magali |
AuthorAffiliation | 2 Faculté de médecine, Université de Nantes, Nantes, France IPMC, CNRS UMR 7275 UNS, France 4 Service d'Anatomie Pathologique, Hôpital Européen Georges Pompidou, Paris, France 5 Service de Néphrologie et Transplantation Rénale, Hôpital Foch, Suresnes, France 1 Institut National de la Santé Et de la Recherche Médicale INSERM U1064 and Institut de Transplantation Urologie Néphrologie (ITUN), Nantes, France 3 Centre Hospitalier Universitaire, Hôtel Dieu, Nantes, France |
AuthorAffiliation_xml | – name: 5 Service de Néphrologie et Transplantation Rénale, Hôpital Foch, Suresnes, France – name: 1 Institut National de la Santé Et de la Recherche Médicale INSERM U1064 and Institut de Transplantation Urologie Néphrologie (ITUN), Nantes, France – name: 2 Faculté de médecine, Université de Nantes, Nantes, France – name: IPMC, CNRS UMR 7275 UNS, France – name: 4 Service d'Anatomie Pathologique, Hôpital Européen Georges Pompidou, Paris, France – name: 3 Centre Hospitalier Universitaire, Hôtel Dieu, Nantes, France |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23577151$$D View this record in MEDLINE/PubMed https://inserm.hal.science/inserm-02165884$$DView record in HAL |
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ContentType | Journal Article |
Copyright | COPYRIGHT 2013 Public Library of Science 2013 Danger et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Distributed under a Creative Commons Attribution 4.0 International License 2013 Danger et al 2013 Danger et al |
Copyright_xml | – notice: COPYRIGHT 2013 Public Library of Science – notice: 2013 Danger et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: Distributed under a Creative Commons Attribution 4.0 International License – notice: 2013 Danger et al 2013 Danger et al |
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DocumentTitleAlternate | miR-142-5p Is a Potential Biomarker for CAMR |
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Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: RD MG JPDVH JPS SB. Performed the experiments: RD CP AL M. Durand ND AP. Analyzed the data: RD YF M. Durand ND SB. Contributed reagents/materials/analysis tools: YF MG ND SC JPDVH M. Delahousse KR. Wrote the paper: RD JPS SB. |
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Snippet | In renal transplantation, the unresponsiveness of patients undergoing chronic antibody mediated rejection (CAMR) to classical treatment stress on the need for... |
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SubjectTerms | Analysis Antibodies Antibodies - immunology Biology Biomarkers Biomarkers - blood Biomarkers - metabolism Biopsy Blood Blood cells Cancer Cell activation Diagnosis Gene expression Gene Expression Regulation Genes Graft rejection Graft Rejection - blood Graft Rejection - genetics Graft Rejection - immunology Graft Rejection - pathology Histology Human health and pathology Humans Identification Immunology Kidney transplantation Kidney Transplantation - adverse effects Leukocytes (mononuclear) Leukocytes, Mononuclear - metabolism Life Sciences Lymphocytes T Medicine MicroRNA MicroRNAs MicroRNAs - blood MicroRNAs - genetics miRNA Modulation Organ transplant recipients Overexpression Patients Peripheral blood mononuclear cells Rejection Renal failure Renal function Ribonucleic acid RNA T cells Time Factors Transplantation Transplants & implants |
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Title | Expression of miR-142-5p in peripheral blood mononuclear cells from renal transplant patients with chronic antibody-mediated rejection |
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