Fibrinogen-like protein 2/fibroleukin induces long-term allograft survival in a rat model through regulatory B cells

• Published in: PloS one Vol. 10; no. 3; p. e0119686
• Main Authors: Bézie, Séverine, Picarda, Elodie, Tesson, Laurent, Renaudin, Karine, Durand, Justine, Ménoret, Séverine, Mérieau, Emmanuel, Chiffoleau, Elise, Guillonneau, Carole, Caron, Lise, Anegon, Ignacio
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.03.2015; Public Library of Science (PLoS)
• Subjects: Adenoviruses; Adoptive transfer; Allografts; Allografts - transplantation; Animals; B cells; B-Lymphocytes, Regulatory - metabolism; CD4 antigen; CD8 antigen; Cell proliferation; Cell survival; Dendritic cells; Fgl2 protein; Fibrin; Fibrinogen; Fibrinogen - administration & dosage; Fibrinogen - genetics; Gene expression; Gene transfer; Gene Transfer Techniques; Genomes; Graft rejection; Graft Rejection - genetics; Graft Rejection - metabolism; Graft Rejection - prevention & control; Graft Rejection - therapy; Graft Survival; Haplotypes; Heart; Heart diseases; Heart transplantation; Human health and pathology; Immunological tolerance; Immunoregulation; Iterative methods; Life Sciences; Lymphocytes; Lymphocytes B; Lymphocytes T; Male; Overexpression; Plasmids; Proteins; Rats; Rejection; Rodents; Splenocytes; Studies; Survival; T cells; Transplantation; Transplants & implants; Viruses; France; Norway

We previously described that in a rat model of heart transplantation tolerance was dependent on CD8+CD45RClow Tregs that over-expressed fibrinogen-like protein 2 (FGL2)/fibroleukin. Little is known on the immunoregulatory properties of FGL2. Here we analyzed the transplantation tolerance mechanisms...