Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever

Thomas Geisbert and colleagues show that a cocktail of monoclonal antibodies protects cynomolgus monkeys from lethal Lassa fever virus infection, including when administration is delayed by more than a week after viral challenge. There are no approved treatments for Lassa fever, which is endemic to...

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Published inNature medicine Vol. 23; no. 10; pp. 1146 - 1149
Main Authors Mire, Chad E, Cross, Robert W, Geisbert, Joan B, Borisevich, Viktoriya, Agans, Krystle N, Deer, Daniel J, Heinrich, Megan L, Rowland, Megan M, Goba, Augustine, Momoh, Mambu, Boisen, Mathew L, Grant, Donald S, Fullah, Mohamed, Khan, Sheik Humarr, Fenton, Karla A, Robinson, James E, Branco, Luis M, Garry, Robert F, Geisbert, Thomas W
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.10.2017
Nature Publishing Group
Subjects
13/1
13/51
631/326/596/1961
692/699/255/2514
Animals
Antibodies
Antibodies, Monoclonal - therapeutic use
Antibodies, Neutralizing - therapeutic use
Antibodies, Viral - therapeutic use
Biomedicine
brief-communication
Cancer Research
Care and treatment
Cross Reactions
Drug dosages
Drug therapy
Enzyme-Linked Immunosorbent Assay
Fatalities
Fever
Glycoproteins
Health aspects
Humans
Immune Evasion - genetics
Immunohistochemistry
Immunology
Immunotherapy
Infectious Diseases
Lassa fever
Lassa Fever - prevention & control
Lassa virus - genetics
Macaca fascicularis
Medicine
Metabolic Diseases
Molecular Medicine
Monoclonal antibodies
Neurosciences
Plasma
Primates
Random Allocation
RNA, Viral - blood
Survival Rate
Vaccines
Viral diseases
Viral Load
Viruses
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Abstract Thomas Geisbert and colleagues show that a cocktail of monoclonal antibodies protects cynomolgus monkeys from lethal Lassa fever virus infection, including when administration is delayed by more than a week after viral challenge. There are no approved treatments for Lassa fever, which is endemic to the same regions of West Africa that were recently devastated by Ebola. Here we show that a combination of human monoclonal antibodies that cross-react with the glycoproteins of all four clades of Lassa virus is able to rescue 100% of cynomolgus macaques when treatment is initiated at advanced stages of disease, including up to 8 d after challenge.
AbstractList Thomas Geisbert and colleagues show that a cocktail of monoclonal antibodies protects cynomolgus monkeys from lethal Lassa fever virus infection, including when administration is delayed by more than a week after viral challenge.There are no approved treatments for Lassa fever, which is endemic to the same regions of West Africa that were recently devastated by Ebola. Here we show that a combination of human monoclonal antibodies that cross-react with the glycoproteins of all four clades of Lassa virus is able to rescue 100% of cynomolgus macaques when treatment is initiated at advanced stages of disease, including up to 8 d after challenge.
Thomas Geisbert and colleagues show that a cocktail of monoclonal antibodies protects cynomolgus monkeys from lethal Lassa fever virus infection, including when administration is delayed by more than a week after viral challenge. There are no approved treatments for Lassa fever, which is endemic to the same regions of West Africa that were recently devastated by Ebola. Here we show that a combination of human monoclonal antibodies that cross-react with the glycoproteins of all four clades of Lassa virus is able to rescue 100% of cynomolgus macaques when treatment is initiated at advanced stages of disease, including up to 8 d after challenge.
There are no approved treatments for Lassa fever, which is endemic to the same regions of West Africa that were recently devastated by Ebola. Here we show that a combination of human monoclonal antibodies that cross-react with the glycoproteins of all four clades of Lassa virus is able to rescue 100% of cynomolgus macaques when treatment is initiated at advanced stages of disease, including up to 8 d after challenge.
There are no approved treatments for Lassa fever, which is endemic to the same regions of West Africa that were recently devastated by Ebola. Here we show that a combination of human monoclonal antibodies that cross-react with the glycoproteins of all four clades of Lassa virus is able to rescue 100% of cynomolgus macaques when treatment is initiated at advanced stages of disease, including up to 8 d after challenge.There are no approved treatments for Lassa fever, which is endemic to the same regions of West Africa that were recently devastated by Ebola. Here we show that a combination of human monoclonal antibodies that cross-react with the glycoproteins of all four clades of Lassa virus is able to rescue 100% of cynomolgus macaques when treatment is initiated at advanced stages of disease, including up to 8 d after challenge.
Audience Academic
Author Heinrich, Megan L
Borisevich, Viktoriya
Geisbert, Joan B
Fenton, Karla A
Deer, Daniel J
Cross, Robert W
Branco, Luis M
Garry, Robert F
Rowland, Megan M
Fullah, Mohamed
Agans, Krystle N
Momoh, Mambu
Grant, Donald S
Khan, Sheik Humarr
Robinson, James E
Goba, Augustine
Boisen, Mathew L
Mire, Chad E
Geisbert, Thomas W
AuthorAffiliation 9 Tulane Center of Excellence, Global Viral Network, Tulane University, New Orleans, Louisiana, USA
7 Sections of Infectious Disease, Departments of Pediatrics and Internal Medicine, School of Medicine, Tulane University, New Orleans, Louisiana, USA
4 Viral Hemorrhagic Fever Program, Kenema Government Hospital, Kenema, Sierra Leone
5 Ministry of Health and Sanitation, Freetown, Sierra Leone
8 Department of Microbiology and Immunology, Tulane University, New Orleans, Louisiana, USA
3 Zalgen Labs, Germantown, Maryland, USA
1 Department of Microbiology and Immunology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA
2 Galveston National Laboratory, University of Texas Medical Branch at Galveston, Galveston, Texas, USA
6 Polytechnic College, Kenema, Sierra Leone
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/28869611$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1093/infdis/155.3.437
10.3201/eid1610.100774
10.1126/science.282.5396.2079
10.1038/ncomms11544
10.1128/iai.44.2.528-533.1984
10.1371/journal.pntd.0002748
10.1016/S1286-4579(01)01508-8
10.1186/1743-422X-8-314
10.1038/nature14442
10.4269/ajtmh.1970.19.677
10.1016/j.antiviral.2016.08.012
10.1056/NEJM198601023140104
10.1136/bmj.285.6347.1001
10.1126/scitranslmed.3009706
10.1128/JVI.74.15.6777-6783.2000
10.1093/infdis/141.5.580
10.1093/infdis/149.3.420
10.1016/0035-9203(84)90107-X
10.1371/journal.pmed.0020183
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These authors contributed equally to this work.
Deceased.
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References PB Jahrling (BFnm4396_CR8) 1980; 141
H Schmitz (BFnm4396_CR4) 2002; 4
EP Thi (BFnm4396_CR19) 2014; 6
RT Emond (BFnm4396_CR13) 1982; 285
JB McCormick (BFnm4396_CR1) 1987; 155
SP Fisher-Hoch (BFnm4396_CR6) 2000; 74
JN Grove (BFnm4396_CR20) 2011; 8
E Leifer (BFnm4396_CR12) 1970; 19
JD Frame (BFnm4396_CR14) 1984; 78
BFnm4396_CR3
JG Shaffer (BFnm4396_CR2) 2014; 8
TW Geisbert (BFnm4396_CR7) 2005; 2
EP Thi (BFnm4396_CR18) 2015; 521
RW Cross (BFnm4396_CR17) 2016; 133
PB Jahrling (BFnm4396_CR10) 1984; 44
JB McCormick (BFnm4396_CR11) 1986; 314
V Amorosa (BFnm4396_CR5) 2010; 16
PB Jahrling (BFnm4396_CR9) 1984; 149
JE Robinson (BFnm4396_CR16) 2016; 7
W Cao (BFnm4396_CR15) 1998; 282
References_xml – volume: 155
  start-page: 437
  year: 1987
  ident: BFnm4396_CR1
  publication-title: J. Infect. Dis.
  doi: 10.1093/infdis/155.3.437
– volume: 16
  start-page: 1598
  year: 2010
  ident: BFnm4396_CR5
  publication-title: Emerg. Infect. Dis.
  doi: 10.3201/eid1610.100774
– volume: 282
  start-page: 2079
  year: 1998
  ident: BFnm4396_CR15
  publication-title: Science
  doi: 10.1126/science.282.5396.2079
– volume: 7
  start-page: 11544
  year: 2016
  ident: BFnm4396_CR16
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms11544
– volume: 44
  start-page: 528
  year: 1984
  ident: BFnm4396_CR10
  publication-title: Infect. Immun.
  doi: 10.1128/iai.44.2.528-533.1984
– ident: BFnm4396_CR3
– volume: 8
  start-page: e2748
  year: 2014
  ident: BFnm4396_CR2
  publication-title: PLoS Negl. Trop. Dis.
  doi: 10.1371/journal.pntd.0002748
– volume: 4
  start-page: 43
  year: 2002
  ident: BFnm4396_CR4
  publication-title: Microbes Infect.
  doi: 10.1016/S1286-4579(01)01508-8
– volume: 8
  start-page: 314
  year: 2011
  ident: BFnm4396_CR20
  publication-title: Virol. J.
  doi: 10.1186/1743-422X-8-314
– volume: 521
  start-page: 362
  year: 2015
  ident: BFnm4396_CR18
  publication-title: Nature
  doi: 10.1038/nature14442
– volume: 19
  start-page: 677
  year: 1970
  ident: BFnm4396_CR12
  publication-title: Am. J. Trop. Med. Hyg.
  doi: 10.4269/ajtmh.1970.19.677
– volume: 133
  start-page: 218
  year: 2016
  ident: BFnm4396_CR17
  publication-title: Antiviral Res.
  doi: 10.1016/j.antiviral.2016.08.012
– volume: 314
  start-page: 20
  year: 1986
  ident: BFnm4396_CR11
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJM198601023140104
– volume: 285
  start-page: 1001
  year: 1982
  ident: BFnm4396_CR13
  publication-title: Br. Med. J.
  doi: 10.1136/bmj.285.6347.1001
– volume: 6
  start-page: 250ra116
  year: 2014
  ident: BFnm4396_CR19
  publication-title: Sci. Transl. Med.
  doi: 10.1126/scitranslmed.3009706
– volume: 74
  start-page: 6777
  year: 2000
  ident: BFnm4396_CR6
  publication-title: J. Virol.
  doi: 10.1128/JVI.74.15.6777-6783.2000
– volume: 141
  start-page: 580
  year: 1980
  ident: BFnm4396_CR8
  publication-title: J. Infect. Dis.
  doi: 10.1093/infdis/141.5.580
– volume: 149
  start-page: 420
  year: 1984
  ident: BFnm4396_CR9
  publication-title: J. Infect. Dis.
  doi: 10.1093/infdis/149.3.420
– volume: 78
  start-page: 319
  year: 1984
  ident: BFnm4396_CR14
  publication-title: Trans. R. Soc. Trop. Med. Hyg.
  doi: 10.1016/0035-9203(84)90107-X
– volume: 2
  start-page: e183
  year: 2005
  ident: BFnm4396_CR7
  publication-title: PLoS Med.
  doi: 10.1371/journal.pmed.0020183
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Snippet Thomas Geisbert and colleagues show that a cocktail of monoclonal antibodies protects cynomolgus monkeys from lethal Lassa fever virus infection, including...
There are no approved treatments for Lassa fever, which is endemic to the same regions of West Africa that were recently devastated by Ebola. Here we show that...
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SubjectTerms 13/1
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631/326/596/1961
692/699/255/2514
Animals
Antibodies
Antibodies, Monoclonal - therapeutic use
Antibodies, Neutralizing - therapeutic use
Antibodies, Viral - therapeutic use
Biomedicine
brief-communication
Cancer Research
Care and treatment
Cross Reactions
Drug dosages
Drug therapy
Enzyme-Linked Immunosorbent Assay
Fatalities
Fever
Glycoproteins
Health aspects
Humans
Immune Evasion - genetics
Immunohistochemistry
Immunology
Immunotherapy
Infectious Diseases
Lassa fever
Lassa Fever - prevention & control
Lassa virus - genetics
Macaca fascicularis
Medicine
Metabolic Diseases
Molecular Medicine
Monoclonal antibodies
Neurosciences
Plasma
Primates
Random Allocation
RNA, Viral - blood
Survival Rate
Vaccines
Viral diseases
Viral Load
Viruses
Title Human-monoclonal-antibody therapy protects nonhuman primates against advanced Lassa fever
URI https://link.springer.com/article/10.1038/nm.4396
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