STAT3 signaling controls satellite cell expansion and skeletal muscle repair

• Published in: Nature medicine Vol. 20; no. 10; pp. 1182 - 1186
• Main Authors: Tierney, Matthew Timothy, Aydogdu, Tufan, Sala, David, Malecova, Barbora, Gatto, Sole, Puri, Pier Lorenzo, Latella, Lucia, Sacco, Alessandra
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.10.2014; Nature Publishing Group
• Subjects: 13/31; 14/19; 38/1; 38/15; 38/77; 42/100; 631/532/2439; 631/80/86/2368; 64/60; Ablation; Age; Aging - genetics; Aging - pathology; Aging - physiology; Analysis; Animals; Biomedicine; Cancer Research; Cell fate; Cell Proliferation; Cell self-renewal; Cells, Cultured; Cellular biology; Cytokines; Depletion; Differentiation; Gene expression; Humans; Infectious Diseases; Inflammation; Interleukin 6; letter; Male; Metabolic Diseases; Mice; Mice, Inbred C57BL; Mice, Inbred mdx; Mice, Knockout; Molecular Medicine; Muscle Development - physiology; Muscles; Musculoskeletal system; Myoblasts; MyoD Protein - genetics; MyoD Protein - metabolism; Neurosciences; PAX7 Transcription Factor - metabolism; Physiological aspects; Regeneration; Regeneration - physiology; Repair; Satellite cells; Satellite Cells, Skeletal Muscle - cytology; Satellite Cells, Skeletal Muscle - physiology; Signal Transduction; Signaling; Skeletal muscle; Stat3 protein; STAT3 Transcription Factor - antagonists & inhibitors; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - physiology; Stem cells

In two new reports, STAT3 signaling is shown to be increased in adult muscle satellite cells, and its inhibition improves muscle regeneration. The progressive loss of muscle regenerative capacity with age or disease results in part from a decline in the number and function of satellite cells, the di...