Adenovirus-mediated hAQP1 expression in irradiated mouse salivary glands causes recovery of saliva secretion by enhancing acinar cell volume decrease

• Published in: Gene therapy Vol. 23; no. 7; pp. 572 - 579
• Main Authors: Teos, L Y, Zheng, C-Y, Liu, X, Swaim, W D, Goldsmith, C M, Cotrim, A P, Baum, B J, Ambudkar, I S
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2016; Nature Publishing Group
• Subjects: 14/19; 42/34; 42/41; 631/61/201; 64/60; 82/1; 96/109; 96/34; Acinar cells; Acinar Cells - cytology; Acinar Cells - metabolism; Acinar Cells - radiation effects; Adenoviridae - genetics; Adenoviruses; Animal models; Animals; Aquaporin 1 - genetics; Aquaporin 1 - metabolism; Aquaporins; Biomedical and Life Sciences; Biomedicine; Body fluids; Cancer therapies; Carbachol; Care and treatment; Causes of; Cell Biology; Cell Line; Cell Size; Cells, Cultured; Cellular biology; Complications and side effects; Exocrine glands; Gene Expression; Gene Therapy; Genetic aspects; Genetic Therapy - methods; Genetic Vectors - genetics; Head & neck cancer; Health aspects; Human Genetics; Humans; I.R. radiation; Methods; Mice; Nanotechnology; original-article; Permeability; Physiological aspects; Properties; Radiation, Ionizing; Radiotherapy; Rats; Saliva; Saliva - metabolism; Salivary gland; Salivary glands; Salivary Glands - cytology; Salivary Glands - metabolism; Salivary Glands - radiation effects; Salivation; Secretion; Submandibular gland; Xerostomia; United States

Head and neck irradiation (IR) during cancer treatment causes by-stander effects on the salivary glands leading to irreversible loss of saliva secretion. The mechanism underlying loss of fluid secretion is not understood and no adequate therapy is currently available. Delivery of an adenoviral vecto...