Suppression of Dopamine Neurons Mediates Reward

• Published in: PLoS biology Vol. 14; no. 12; p. e1002586
• Main Authors: Yamagata, Nobuhiro, Hiroi, Makoto, Kondo, Shu, Abe, Ayako, Tanimoto, Hiromu
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.12.2016; Public Library of Science (PLoS)
• Subjects: Animals; Biology and Life Sciences; Brain research; Dopamine; Dopaminergic Neurons - metabolism; Dopaminergic Neurons - physiology; Drosophila melanogaster; Drug abuse; Experiments; Funding; Health aspects; Heterogeneity; Inactivation; Ingestion; Insects; Laboratories; Life sciences; Medicine and Health Sciences; Mesencephalon - cytology; Mesencephalon - metabolism; Mushroom Bodies - metabolism; Neural circuitry; Neurons; Neuropeptides; Peptides - physiology; Physical Sciences; Research and Analysis Methods; Reward; Signal Transduction; Social Sciences; Sugar; University graduates

Massive activation of dopamine neurons is critical for natural reward and drug abuse. In contrast, the significance of their spontaneous activity remains elusive. In Drosophila melanogaster, depolarization of the protocerebral anterior medial (PAM) cluster dopamine neurons en masse signals reward to...