Common Genetic Origins for EEG, Alcoholism and Anxiety: The Role of CRH-BP

• Published in: PloS one Vol. 3; no. 10; p. e3620
• Main Authors: Enoch, Mary-Anne, Shen, Pei-Hong, Ducci, Francesca, Yuan, Qiaoping, Liu, Jixia, White, Kenneth V., Albaugh, Bernard, Hodgkinson, Colin A., Goldman, David
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 31.10.2008; Public Library of Science (PLoS)
• Subjects: Addictions; Alcoholism; Alcoholism - ethnology; Alcoholism - genetics; Alcohols; Anxiety; Anxiety - ethnology; Anxiety - genetics; Arousal; Brain - physiology; Carrier Proteins - genetics; Carrier Proteins - physiology; Chromosome 5; Chromosomes, Human, Pair 5; Cognitive ability; Consciousness; Convergence; Cortex; Corticotropin; Corticotropin-releasing hormone; Disorders; Drug abuse; EEG; Electroencephalography; Environment; Frequencies; Genetic aspects; Genetics and Genomics/Complex Traits; Genetics and Genomics/Genetics of Disease; Genome-Wide Association Study; Genomes; Genomics; Haplotypes; Hippocampus; Humans; Linkage Disequilibrium; Native Americans; Neurohormones; Neurological Disorders/Neurogenetics; Neurological Disorders/Neuropsychiatric Disorders; Neuroscience/Behavioral Neuroscience; Pedigree; Phenotype; Polymorphism, Single Nucleotide; Protein binding; Quantitative Trait, Heritable; Rest - physiology; Single-nucleotide polymorphism; Spectrum analysis; Studies; United States > US; Maryland

The resting EEG is a dynamic index of cortical activation, cognitive function and consciousness and is therefore an intermediate phenotype for many behaviors in which arousal is implicated such as anxiety and alcoholism. We performed a dense whole genome linkage scan using 3878 unlinked SNPs in a la...