Increased flexibility of the SARS-CoV-2 RNA-binding site causes resistance to remdesivir

• Published in: PLoS pathogens Vol. 19; no. 3; p. e1011231
• Main Authors: Torii, Shiho, Kim, Kwang Su, Koseki, Jun, Suzuki, Rigel, Iwanami, Shoya, Fujita, Yasuhisa, Jeong, Yong Dam, Ito, Jumpei, Asakura, Hiroyuki, Nagashima, Mami, Sadamasu, Kenji, Yoshimura, Kazuhisa, Sato, Kei, Matsuura, Yoshiharu, Shimamura, Teppei, Iwami, Shingo, Fukuhara, Takasuke
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 27.03.2023; Public Library of Science (PLoS)
• Subjects: Amino acids; Analysis; Antiviral activity; Antiviral Agents - metabolism; Antiviral drugs; Binding Sites; Biology and life sciences; Cloning; Coronaviruses; COVID-19; COVID-19 Drug Treatment; Drug resistance; Epidemics; FDA approval; Flexibility; Genomes; Genomics; Health aspects; Humans; Infection; Japan; Mathematical models; Medical research; Medicine and health sciences; Medicine, Experimental; Molecular dynamics; Mutagenesis; Mutants; Mutation; Physical Sciences; Prevention; Ribonucleic acid; RNA; RNA polymerase; RNA, Viral; SARS-CoV-2 - metabolism; Severe acute respiratory syndrome coronavirus 2; Vibration; Viral diseases; Virus diseases; Viruses; Japan

Mutations continue to accumulate within the SARS-CoV-2 genome, and the ongoing epidemic has shown no signs of ending. It is critical to predict problematic mutations that may arise in clinical environments and assess their properties in advance to quickly implement countermeasures against future var...