Increased flexibility of the SARS-CoV-2 RNA-binding site causes resistance to remdesivir - Torii, Shiho; Kim, Kwang Su; Koseki, Jun; Suzuki, Rigel; Iwanami, Shoya; Fujita, Yasuhisa; Jeong, Yong Dam; Ito, Jumpei; Asakura, Hiroyuki; Nagashima, Mami; Sadamasu, Kenji; Yoshimura, Kazuhisa; et al. (PLoS pathogens, 2023)
Keywords: Amino acids; Analysis; Antiviral activity; Antiviral Agents - metabolism; Antiviral drugs; Binding Sites; Biology and life sciences; Cloning; Coronaviruses; COVID-19; COVID-19 Drug Treatment; Drug resistance; Epidemics; FDA approval; Flexibility; Genomes; Genomics; Health aspects; Humans; Infection; Japan; Mathematical models; Medical research; Medicine and health sciences; Medicine, Experimental; Molecular dynamics; Mutagenesis; Mutants; Mutation; Physical Sciences; Prevention; Ribonucleic acid; RNA; RNA polymerase; RNA, Viral; SARS-CoV-2 - metabolism; Severe acute respiratory syndrome coronavirus 2; Vibration; Viral diseases; Virus diseases; Viruses; Japan