Reduction of conformational mobility and aggregation in W60G β 2 ‐microglobulin: assessment by 15 N NMR relaxation

• Published in: Magnetic resonance in chemistry Vol. 51; no. 12; pp. 795 - 807
• Main Authors: Gümral, Devrim, Fogolari, Federico, Corazza, Alessandra, Viglino, Paolo, Giorgetti, Sofia, Stoppini, Monica, Bellotti, Vittorio, Esposito, Gennaro
• Format: Journal Article
• Language: English
• Published: 01.12.2013

The amyloid pathology associated with long‐term haemodialysis is due to the deposition of β 2 ‐microglobulin, the non‐polymorphic light chain of class I major histocompatibility complex, that accumulates at bone joints into amyloid fibrils. Several lines of evidence show the relevance of the tryptop...