Phosphorylation of the HIV-1 capsid by MELK triggers uncoating to promote viral cDNA synthesis - Takeuchi, Hiroaki; Saito, Hideki; Noda, Takeshi; Miyamoto, Tadashi; Yoshinaga, Tomokazu; Terahara, Kazutaka; Ishii, Hiroshi; Tsunetsugu-Yokota, Yasuko; Yamaoka, Shoji (PLoS pathogens, 2017)
Keywords: Acquired immune deficiency syndrome; AIDS; Amino acid substitution; Amino acids; Biology and Life Sciences; Capsid - metabolism; Cell Line; Chemical synthesis; Dismantling; DNA, Viral - genetics; DNA, Viral - metabolism; Efficiency; Genetic aspects; Genetic screening; Health aspects; HIV; HIV Infections - enzymology; HIV Infections - genetics; HIV Infections - virology; HIV-1 - genetics; HIV-1 - physiology; Host-Pathogen Interactions; Human immunodeficiency virus; Humans; Immunology; Infections; Infectious diseases; Laboratories; Leucine; Leucine zipper proteins; Leukemia; Leukocytes (mononuclear); Leukocytes, Mononuclear - enzymology; Leukocytes, Mononuclear - virology; Lymphocytes T; Medical research; Medicine and Health Sciences; Mutation; Peripheral blood mononuclear cells; Phosphorylation; Phosphotransferases; Physical Sciences; Protein-Serine-Threonine Kinases - genetics; Protein-Serine-Threonine Kinases - metabolism; Proteins; R&D; Research & development; Research and analysis methods; Science; Uncoating; Virology; Virulence (Microbiology); Virus Replication; Virus Uncoating; Viruses; Japan