Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides

• Published in: PLoS pathogens Vol. 8; no. 11; p. e1003030
• Main Authors: Arnold, Jamie J., Sharma, Suresh D., Feng, Joy Y., Ray, Adrian S., Smidansky, Eric D., Kireeva, Maria L., Cho, Aesop, Perry, Jason, Vela, Jennifer E., Park, Yeojin, Xu, Yili, Tian, Yang, Babusis, Darius, Barauskus, Ona, Peterson, Blake R., Gnatt, Averell, Kashlev, Mikhail, Zhong, Weidong, Cameron, Craig E.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.11.2012; Public Library of Science (PLoS)
• Subjects: Animals; Antiviral agents; Antiviral Agents - adverse effects; Antiviral Agents - pharmacology; Biology; Cancer; Cattle; Cell Line; Cell Nucleus - metabolism; DNA-Directed RNA Polymerases - metabolism; Dosage and administration; Drug therapy; Genetic aspects; Genetic transcription; Health aspects; Hepacivirus - metabolism; Hepatitis C; Hepatitis C - drug therapy; Hepatitis C - enzymology; Medicine; Metabolites; Mitochondria; Mitochondria - metabolism; Mitochondrial DNA; Physiological aspects; Ribonucleosides - adverse effects; Ribonucleosides - pharmacology; RNA polymerase; RNA Polymerase II - metabolism; RNA polymerases; RNA, Viral - biosynthesis; Studies; Toxicity; Transcription, Genetic - drug effects; Viral genetics; United States

Ribonucleoside analogues have potential utility as anti-viral, -parasitic, -bacterial and -cancer agents. However, their clinical applications have been limited by off target effects. Development of antiviral ribonucleosides for treatment of hepatitis C virus (HCV) infection has been hampered by app...