K18-hACE2 mice develop respiratory disease resembling severe COVID-19

• Published in: PLoS pathogens Vol. 17; no. 1; p. e1009195
• Main Authors: Yinda, Claude Kwe, Port, Julia R., Bushmaker, Trenton, Offei Owusu, Irene, Purushotham, Jyothi N., Avanzato, Victoria A., Fischer, Robert J., Schulz, Jonathan E., Holbrook, Myndi G., Hebner, Madison J., Rosenke, Rebecca, Thomas, Tina, Marzi, Andrea, Best, Sonja M., de Wit, Emmie, Shaia, Carl, van Doremalen, Neeltje, Munster, Vincent J.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 19.01.2021; Public Library of Science (PLoS)
• Subjects: Alveoli; Angiotensin-Converting Enzyme 2 - genetics; Angiotensin-Converting Enzyme 2 - immunology; Animals; Antigens; Biology and life sciences; Coronaviruses; COVID-19; COVID-19 - genetics; COVID-19 - immunology; COVID-19 - pathology; COVID-19 - virology; Cytokeratin; Disease Models, Animal; Dose-response relationship (Biochemistry); Edema; Engineering and Technology; Epithelial cells; Female; Fibrin; Gastrointestinal system; Gastrointestinal tract; Gene expression; Genomes; Health aspects; Humans; Hyperplasia; Immunoreactivity; Infections; Inflammation; Irradiated; Keratin-18 - genetics; Keratin-18 - immunology; Kidneys; Leukocytes (neutrophilic); Lung - immunology; Lung - pathology; Lungs; Lymphocytes; Lymphocytes - immunology; Macrophages; Macrophages - immunology; Male; Medicine and health sciences; Mice; Mice, Transgenic; Necrosis; Neutrophils; Organs; Pathology; Pneumocytes; Pneumonia; Promoter Regions, Genetic; Promoters (Genetics); Rectum; Research and Analysis Methods; Respiratory diseases; SARS-CoV-2 - physiology; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Shedding; Trachea - immunology; Trachea - virology; Transgenic animals; Viral diseases; Viruses; United States

SARS-CoV-2 emerged in late 2019 and resulted in the ongoing COVID-19 pandemic. Several animal models have been rapidly developed that recapitulate the asymptomatic to moderate disease spectrum. Now, there is a direct need for additional small animal models to study the pathogenesis of severe COVID-1...