K18-hACE2 mice develop respiratory disease resembling severe COVID-19 - Yinda, Claude Kwe; Port, Julia R.; Bushmaker, Trenton; Offei Owusu, Irene; Purushotham, Jyothi N.; Avanzato, Victoria A.; Fischer, Robert J.; Schulz, Jonathan E.; Holbrook, Myndi G.; Hebner, Madison J.; Rosenke, Rebecca; Thomas, Tina; et al. (PLoS pathogens, 2021)
Keywords: Alveoli; Angiotensin-Converting Enzyme 2 - genetics; Angiotensin-Converting Enzyme 2 - immunology; Animals; Antigens; Biology and life sciences; Coronaviruses; COVID-19; COVID-19 - genetics; COVID-19 - immunology; COVID-19 - pathology; COVID-19 - virology; Cytokeratin; Disease Models, Animal; Dose-response relationship (Biochemistry); Edema; Engineering and Technology; Epithelial cells; Female; Fibrin; Gastrointestinal system; Gastrointestinal tract; Gene expression; Genomes; Health aspects; Humans; Hyperplasia; Immunoreactivity; Infections; Inflammation; Irradiated; Keratin-18 - genetics; Keratin-18 - immunology; Kidneys; Leukocytes (neutrophilic); Lung - immunology; Lung - pathology; Lungs; Lymphocytes; Lymphocytes - immunology; Macrophages; Macrophages - immunology; Male; Medicine and health sciences; Mice; Mice, Transgenic; Necrosis; Neutrophils; Organs; Pathology; Pneumocytes; Pneumonia; Promoter Regions, Genetic; Promoters (Genetics); Rectum; Research and Analysis Methods; Respiratory diseases; SARS-CoV-2 - physiology; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Shedding; Trachea - immunology; Trachea - virology; Transgenic animals; Viral diseases; Viruses; United States