Species-Specific Inhibition of RIG-I Ubiquitination and IFN Induction by the Influenza A Virus NS1 Protein

• Published in: PLoS pathogens Vol. 8; no. 11; p. e1003059
• Main Authors: Rajsbaum, Ricardo, Albrecht, Randy A., Wang, May K., Maharaj, Natalya P., Versteeg, Gijs A., Nistal-Villán, Estanislao, García-Sastre, Adolfo, Gack, Michaela U.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.11.2012; Public Library of Science (PLoS)
• Subjects: Animals; Biology; Chlorocebus aethiops; DEAD Box Protein 58; DEAD-box RNA Helicases - genetics; DEAD-box RNA Helicases - metabolism; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Dogs; Health aspects; HeLa Cells; Hogs; Humans; Immune response; Infections; Influenza; Influenza A virus - genetics; Influenza A virus - metabolism; Influenza viruses; Influenza, Human - genetics; Influenza, Human - metabolism; Interferon; Interferons - biosynthesis; Interferons - genetics; Medicine; Mice; Mice, Knockout; Microscopy; Physiological aspects; Proteins; Receptors, Immunologic; Swine; Transcription Factors - genetics; Transcription Factors - metabolism; Tripartite Motif Proteins; Ubiquitin-proteasome system; Ubiquitin-Protein Ligases - genetics; Ubiquitin-Protein Ligases - metabolism; Ubiquitination; Vero Cells; Viral Nonstructural Proteins - genetics; Viral Nonstructural Proteins - metabolism; Viral proteins; Virulence (Microbiology); Viruses; Spain

Influenza A viruses can adapt to new host species, leading to the emergence of novel pathogenic strains. There is evidence that highly pathogenic viruses encode for non-structural 1 (NS1) proteins that are more efficient in suppressing the host immune response. The NS1 protein inhibits type-I interf...