Inflammatory monocytes mediate control of acute alphavirus infection in mice

• Published in: PLoS pathogens Vol. 13; no. 12; p. e1006748
• Main Authors: Haist, Kelsey C., Burrack, Kristina S., Davenport, Bennett J., Morrison, Thomas E.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 15.12.2017; Public Library of Science (PLoS)
• Subjects: Adaptive immunity; Alphavirus; Aquatic insects; Biology and Life Sciences; Bone marrow; CCR2 protein; Cell culture; Cell cycle; Chikungunya virus; Depletion; Development and progression; Epidemics; Funding; Gene expression; Health services; Immunity; Immunology; Infections; Infectious diseases; Inflammation; Interferon; Interferon regulatory factor 3; Interferon regulatory factor 7; Killer cells; Leukocytes (neutrophilic); Macrophages; Medicine; Medicine and Health Sciences; Mice; Monocyte chemoattractant protein 1; Monocytes; Mosquitoes; Muscles; Musculoskeletal diseases; Mutation; Neutrophils; Pathogenesis; Physiological aspects; Proteins; Public health; RAG1 protein; Research and Analysis Methods; Ribonucleic acid; RNA; RNA virus infections; Toxins; Transgenic mice; Vector-borne diseases; Viral infections; Virology; Virulence; Viruses; United States

Chikungunya virus (CHIKV) and Ross River virus (RRV) are mosquito-transmitted alphaviruses that cause debilitating acute and chronic musculoskeletal disease. Monocytes are implicated in the pathogenesis of these infections; however, their specific roles are not well defined. To investigate the role...