Interferon signaling suppresses the unfolded protein response and induces cell death in hepatocytes accumulating hepatitis B surface antigen

• Published in: PLoS pathogens Vol. 17; no. 5; p. e1009228
• Main Authors: Baudi, Ian, Isogawa, Masanori, Moalli, Federica, Onishi, Masaya, Kawashima, Keigo, Ishida, Yuji, Tateno, Chise, Sato, Yusuke, Harashima, Hideyoshi, Ito, Hiroyasu, Ishikawa, Tetsuya, Wakita, Takaji, Iannacone, Matteo, Tanaka, Yasuhito
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.05.2021; Public Library of Science (PLoS)
• Subjects: Accumulation; Antibodies; Antigens; Apoptosis; Biology and Life Sciences; Care and treatment; Cell death; Cellular signal transduction; Cluster analysis; Development and progression; DNA microarrays; Engineering and Technology; Genetic aspects; Health aspects; Hepatitis; Hepatitis associated antigen; Hepatitis B; Hepatitis B surface antigen; Hepatocytes; Injuries; Interferon; Liver; Medicine and Health Sciences; Nitric oxide; Nitric-oxide synthase; Phosphorylation; Protein folding; Protein synthesis; Proteins; Research and Analysis Methods; Ribonuclease L; Rodents; Salt; Signaling; Viral infections; α-Interferon; Japan

Virus infection, such as hepatitis B virus (HBV), occasionally causes endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) is counteractive machinery to ER stress, and the failure of UPR to cope with ER stress results in cell death. Mechanisms that regulate the balance between ER s...