Ecdysone-controlled nuclear receptor ERR regulates metabolic homeostasis in the disease vector mosquito Aedes aegypti

• Published in: PLoS genetics Vol. 20; no. 3; p. e1011196
• Main Authors: Geng, Dan-Qian, Wang, Xue-Li, Lyu, Xiang-Yang, Raikhel, Alexander S., Zou, Zhen
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 11.03.2024; Public Library of Science (PLoS)
• Subjects: Aedes aegypti; Biology and Life Sciences; Carbohydrate metabolism; Culicidae; Dengue fever; Down-regulation; Ecdysone; Electrophoretic mobility; Fatty-acid synthase; Females; Gene expression; Genetic aspects; Genetic engineering; Glucose isomerase; Glucose metabolism; Glucose-6-phosphate isomerase; Glycogen; Homeostasis; Hormones; Insects; Medicine and Health Sciences; Metabolism; Metabolites; Mosquitoes; mRNA; Pituitary (anterior); Pyruvate kinase; Pyruvic acid; Reproductive status; Research and Analysis Methods; RNA-mediated interference; Trehalose; Tropical diseases; Vectors; Zika virus; United States

Hematophagous mosquitoes require vertebrate blood for their reproductive cycles, making them effective vectors for transmitting dangerous human diseases. Thus, high-intensity metabolism is needed to support reproductive events of female mosquitoes. However, the regulatory mechanism linking metabolis...