Identification of Interactions between Sindbis Virus Capsid Protein and Cytoplasmic vRNA as Novel Virulence Determinants

• Published in: PLoS pathogens Vol. 13; no. 6; p. e1006473
• Main Authors: Sokoloski, Kevin J., Nease, Lauren M., May, Nicholas A., Gebhart, Natasha N., Jones, Claire E., Morrison, Thomas E., Hardy, Richard W.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 29.06.2017; Public Library of Science (PLoS)
• Subjects: Animal models; Animals; Biology; Biology and Life Sciences; Capsid - metabolism; Capsid protein; Capsid Proteins - metabolism; Cargo; Cores; Cytoplasm; Cytoplasm - metabolism; Funding; Gene expression; Gene sequencing; Genome, Viral - genetics; Genomes; Genomics; Growth kinetics; Immunology; Infections; Infectious diseases; Infectivity; Kinetics; Medicine; Mosquitoes; Mutants; Mutation; Nucleic acids; Nucleocapsids; Nucleotide sequence; Particle production; Physiological aspects; Proteins; Public health; Research and analysis methods; Ribonucleic acid; RNA; RNA viruses; RNA, Viral - metabolism; Roles; Sindbis Virus - genetics; Sindbis Virus - metabolism; Sindbis Virus - pathogenicity; Supervision; Viral Envelope Proteins - metabolism; Viral proteins; Virion - metabolism; Virology; Virulence; Virulence (Microbiology); Virulence - physiology; Virus Assembly - physiology; Viruses

Alphaviruses are arthropod-borne viruses that represent a significant threat to public health at a global level. While the formation of alphaviral nucleocapsid cores, consisting of cargo nucleic acid and the viral capsid protein, is an essential molecular process of infection, the precise interactio...