Genetic epidemiology, genetic maps and positional cloning

Genetic epidemiology developed in the middle of the last century, focused on inherited causes of disease but with methods and results applicable to other traits and even forensics. Early success with linkage led to the localization of genes contributing to disease, and ultimately to the Human Genome...

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Published inPhilosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 358; no. 1438; pp. 1701 - 1708
Main Author Morton, Newton E.
Format Journal Article
LanguageEnglish
Published England The Royal Society 29.10.2003
Subjects
Biobank
Chromosome Mapping
DNA
Epidemiology
Ethics
Evolutionary genetics
Forensic genetics
Genetic loci
Genetic mapping
Genetic Markers - genetics
Genetic Predisposition to Disease - epidemiology
Genetic Research - ethics
Genetic Research - legislation & jurisprudence
Genotype
Haplotypes
Haplotypes - genetics
HapMap
Human genetics
Humans
Linkage
Linkage Disequilibrium
Linkage Disequilibrium - genetics
Medical genetics
Population genetics
Research Subjects
Single Nucleotide Polymorphism
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Abstract Genetic epidemiology developed in the middle of the last century, focused on inherited causes of disease but with methods and results applicable to other traits and even forensics. Early success with linkage led to the localization of genes contributing to disease, and ultimately to the Human Genome Project. The discovery of millions of DNA markers has encouraged more efficient positional cloning by linkage disequilibrium (LD), using LD maps and haplotypes in ways that are rapidly evolving. This has led to large international programmes, some promising and others alarming, with laws about DNA patenting and ethical guidelines for responsible research still struggling to be born.
AbstractList Genetic epidemiology developed in the middle of the last century, focused on inherited causes of disease but with methods and results applicable to other traits and even forensics. Early success with linkage led to the localization of genes contributing to disease, and ultimately to the Human Genome Project. The discovery of millions of DNA markers has encouraged more efficient positional cloning by linkage disequilibrium (LD), using LD maps and haplotypes in ways that are rapidly evolving. This has led to large international programmes, some promising and others alarming, with laws about DNA patenting and ethical guidelines for responsible research still struggling to be born.
Genetic epidemiology developed in the middle of the last century, focused on inherited causes of disease but with methods and results applicable to other traits and even forensics. Early success with linkage led to the localization of genes contributing to disease, and ultimately to the Human Genome Project. The discovery of millions of DNA markers has encouraged more efficient positional cloning by linkage disequilibrium (LD), using LD maps and haplotypes in ways that are rapidly evolving. This has led to large international programmes, some promising and others alarming, with laws about DNA patenting and ethical guidelines for responsible research still struggling to be born.Genetic epidemiology developed in the middle of the last century, focused on inherited causes of disease but with methods and results applicable to other traits and even forensics. Early success with linkage led to the localization of genes contributing to disease, and ultimately to the Human Genome Project. The discovery of millions of DNA markers has encouraged more efficient positional cloning by linkage disequilibrium (LD), using LD maps and haplotypes in ways that are rapidly evolving. This has led to large international programmes, some promising and others alarming, with laws about DNA patenting and ethical guidelines for responsible research still struggling to be born.
Genetic epidemiology developed in the middle of the last century, focused on inherited causes of disease but with methods and results applicable to other traits and even forensics. Early success with linkage led to the localization of genes contributing to disease, and ultimately to the Human Genome Project. The discovery of millions of DNA markers has encouraged more efficient positional cloning by linkage disequilibrium (LD), using LD maps and haplotypes in ways that are rapidly evolving. This has led to large international programmes, some promising and others alarming, with laws about DNA patenting and ethical guidelines for responsible research still struggling to be born.
Author Morton, Newton E.
AuthorAffiliation University of Southampton, Human Genetics Division, Duthie Building, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK. nem@soton.ac.uk
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Snippet Genetic epidemiology developed in the middle of the last century, focused on inherited causes of disease but with methods and results applicable to other...
Genetic epidemiology developed in the middle of the last century, focused on inherited causes of disease but with methods and results applicable to other...
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SubjectTerms Biobank
Chromosome Mapping
DNA
Epidemiology
Ethics
Evolutionary genetics
Forensic genetics
Genetic loci
Genetic mapping
Genetic Markers - genetics
Genetic Predisposition to Disease - epidemiology
Genetic Research - ethics
Genetic Research - legislation & jurisprudence
Genotype
Haplotypes
Haplotypes - genetics
HapMap
Human genetics
Humans
Linkage
Linkage Disequilibrium
Linkage Disequilibrium - genetics
Medical genetics
Population genetics
Research Subjects
Single Nucleotide Polymorphism
Title Genetic epidemiology, genetic maps and positional cloning
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