STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection

• Published in: PLoS pathogens Vol. 16; no. 3; p. e1008335
• Main Authors: Wang, Wenbiao, Hu, Dingwen, Wu, Caifeng, Feng, Yuqian, Li, Aixin, Liu, Weiyong, Wang, Yingchong, Chen, Keli, Tian, Mingfu, Xiao, Feng, Zhang, Qi, Shereen, Muhammad Adnan, Chen, Weijie, Pan, Pan, Wan, Pin, Wu, Kailang, Wu, Jianguo
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.03.2020; Public Library of Science (PLoS)
• Subjects: Activation; Biological response modifiers; Biology and Life Sciences; Cell lines; Cells (Biology); Cytokines; Deoxyribonucleic acid; DNA; Endoplasmic reticulum; Genes; Health aspects; Herpes viruses; IL-1β; Immune response; Immune system; Infection; Infections; Inflammasomes; Inflammation; Innate immunity; Interferon; Laboratories; Life sciences; Localization; Medicine and Health Sciences; Pathogens; Plasmids; Proteins; Research and analysis methods; Stimulators; Virology; China

One of the fundamental reactions of the innate immune responses to pathogen infection is the release of pro-inflammatory cytokines, including IL-1β, processed by the NLRP3 inflammasome. The stimulator of interferon genes (STING) has the essential roles in innate immune response against pathogen infe...