DNA methylation aging clocks: challenges and recommendations

Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological agi...

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Published in	Genome Biology Vol. 20; no. 1; p. 249
Main Authors	Bell, Christopher G., Lowe, Robert, Adams, Peter D., Baccarelli, Andrea A., Beck, Stephan, Bell, Jordana T., Christensen, Brock C., Gladyshev, Vadim N., Heijmans, Bastiaan T., Horvath, Steve, Ideker, Trey, Issa, Jean-Pierre J., Kelsey, Karl T., Marioni, Riccardo E., Reik, Wolf, Relton, Caroline L., Schalkwyk, Leonard C., Teschendorff, Andrew E., Wagner, Wolfgang, Zhang, Kang, Rakyan, Vardhman K.
Format	Journal Article
Language	English
Published	England BioMed Central 25.11.2019 BMC
Subjects	Age Age determination Aging Aging - metabolism Animals Biological Clocks biomarkers Cell culture CpG islands Deoxyribonucleic acid DNA DNA Methylation Epigenesis, Genetic epigenetics epigenome ethics Forensic science forensic sciences Genome, Human Genome-Wide Association Study Humans longevity Population studies Review
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Abstract	Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating interventions. Here, we discuss key challenges to understand clock mechanisms and biomarker utility. This requires dissecting the drivers and regulators of age-related changes in single-cell, tissue- and disease-specific models, as well as exploring other epigenomic marks, longitudinal and diverse population studies, and non-human models. We also highlight important ethical issues in forensic age determination and predicting the trajectory of biological aging in an individual.
AbstractList	Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating interventions. Here, we discuss key challenges to understand clock mechanisms and biomarker utility. This requires dissecting the drivers and regulators of age-related changes in single-cell, tissue- and disease-specific models, as well as exploring other epigenomic marks, longitudinal and diverse population studies, and non-human models. We also highlight important ethical issues in forensic age determination and predicting the trajectory of biological aging in an individual. Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating interventions. Here, we discuss key challenges to understand clock mechanisms and biomarker utility. This requires dissecting the drivers and regulators of age-related changes in single-cell, tissue- and disease-specific models, as well as exploring other epigenomic marks, longitudinal and diverse population studies, and non-human models. We also highlight important ethical issues in forensic age determination and predicting the trajectory of biological aging in an individual.Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating interventions. Here, we discuss key challenges to understand clock mechanisms and biomarker utility. This requires dissecting the drivers and regulators of age-related changes in single-cell, tissue- and disease-specific models, as well as exploring other epigenomic marks, longitudinal and diverse population studies, and non-human models. We also highlight important ethical issues in forensic age determination and predicting the trajectory of biological aging in an individual. Abstract Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating interventions. Here, we discuss key challenges to understand clock mechanisms and biomarker utility. This requires dissecting the drivers and regulators of age-related changes in single-cell, tissue- and disease-specific models, as well as exploring other epigenomic marks, longitudinal and diverse population studies, and non-human models. We also highlight important ethical issues in forensic age determination and predicting the trajectory of biological aging in an individual.
ArticleNumber	249
Author	Adams, Peter D. Issa, Jean-Pierre J. Teschendorff, Andrew E. Kelsey, Karl T. Reik, Wolf Zhang, Kang Relton, Caroline L. Christensen, Brock C. Horvath, Steve Bell, Christopher G. Bell, Jordana T. Rakyan, Vardhman K. Gladyshev, Vadim N. Beck, Stephan Baccarelli, Andrea A. Lowe, Robert Heijmans, Bastiaan T. Ideker, Trey Wagner, Wolfgang Marioni, Riccardo E. Schalkwyk, Leonard C.
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BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31767039$$D View this record in MEDLINE/PubMed
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Snippet	Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular... Abstract Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate...
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SubjectTerms	Age Age determination Aging Aging - metabolism Animals Biological Clocks biomarkers Cell culture CpG islands Deoxyribonucleic acid DNA DNA Methylation Epigenesis, Genetic epigenetics epigenome ethics Forensic science forensic sciences Genome, Human Genome-Wide Association Study Humans longevity Population studies Review
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Title	DNA methylation aging clocks: challenges and recommendations
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