The timing and targeting of treatment in influenza pandemics influences the emergence of resistance in structured populations

• Published in: PLoS computational biology Vol. 9; no. 2; p. e1002912
• Main Authors: Althouse, Benjamin M, Patterson-Lomba, Oscar, Goerg, Georg M, Hébert-Dufresne, Laurent
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.02.2013; Public Library of Science (PLoS)
• Subjects: Antiviral Agents - therapeutic use; Avian flu; Biology; Care and treatment; Chemotherapy; Control; Control theory; Disease transmission; Drug Resistance, Viral; Host-parasite relationships; Humans; Influenza; Influenza, Human - drug therapy; Influenza, Human - epidemiology; Influenza, Human - virology; Mathematical models; Mathematics; Medicine; Models, Biological; Morbidity; Mortality; Pandemics; Population; Social and Behavioral Sciences; Stochastic Processes; Studies; Canada; Pandemics; Stochastic Processes; Models, Biological; Humans; Drug Resistance, Viral; Influenza, Human; Antiviral Agents

Antiviral resistance in influenza is rampant and has the possibility of causing major morbidity and mortality. Previous models have identified treatment regimes to minimize total infections and keep resistance low. However, the bulk of these studies have ignored stochasticity and heterogeneous conta...