HER2-mediated enhancement of Ebola virus entry

• Published in: PLoS pathogens Vol. 16; no. 10; p. e1008900
• Main Authors: Kuroda, Makoto, Halfmann, Peter, Kawaoka, Yoshihiro
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.10.2020; Public Library of Science (PLoS)
• Subjects: AKT1 protein; Animals; Axl protein; Biology and life sciences; Carrier Proteins - metabolism; Cell receptors; Cell surface; Chlorocebus aethiops; Cytotoxicity; Drug development; Drug dosages; Ebola virus; Ebolavirus; Ebolavirus - genetics; Ebolavirus - pathogenicity; Epidermal growth factor; ErbB-2 protein; Experiments; Gene expression; Genetic aspects; Glycoproteins; Growth factors; Health aspects; HEK293 Cells; Hemorrhagic Fever, Ebola - virology; Host-virus relationships; Humans; Infections; Influenza; Inhibitors; Internalization; Kinases; Medicine and Health Sciences; Membrane Glycoproteins - metabolism; Pathogens; Phosphorylation; Phosphotransferases; Protein-tyrosine kinase receptors; Proteins; Receptor Protein-Tyrosine Kinases - metabolism; Receptor, ErbB-2 - metabolism; Receptors; Research and Analysis Methods; RNA polymerase; siRNA; Tyrosine; Vero Cells - virology; Veterinary colleges; Veterinary medicine; Viral diseases; Virulence (Microbiology); Virus Internalization - drug effects; Viruses; United States; United States > US; Japan; Wisconsin

Multiple cell surface molecules including TAM receptors (TYRO3, AXL, and MERTK), a family of tyrosine kinase receptors, can serve as attachment receptors for Ebola virus (EBOV) entry into cells. The interaction of these receptors with EBOV particles is believed to trigger the initial internalization...