Roles of GP33, a guinea pig cytomegalovirus-encoded G protein-coupled receptor homolog, in cellular signaling, viral growth and inflammation in vitro and in vivo

• Published in: PLoS pathogens Vol. 14; no. 12; p. e1007487
• Main Authors: Takeda, Miei, Watanabe, Shinji, Katano, Harutaka, Noguchi, Kazuma, Sato, Yuko, Kojima, Sayaka, Miura, Takuya, Majima, Ryuichi, Yamada, Souichi, Inoue, Naoki
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20.12.2018; Public Library of Science (PLoS)
• Subjects: Alveoli; Analysis; Animal tissues; Animals; Biology and Life Sciences; Cell adhesion & migration; Cellular signal transduction; Cellular structure; Chemokines; Congenital diseases; Cytomegalovirus; Cytomegalovirus infections; Cytomegalovirus Infections - congenital; Cytomegalovirus Infections - immunology; Female; G protein-coupled receptors; G proteins; Genomes; Guinea Pigs; Hemorrhage; Homology; Immune response; Immunology; Infections; Infectious diseases; Inflammation - immunology; Inflammation - virology; Kinases; Laboratories; Lesions; Ligands; Lungs; Medicine and Health Sciences; Mutation; NF-AT protein; NF-κB protein; Organs; Pathogenesis; Pharmaceuticals; Pregnancy; Prenatal Exposure Delayed Effects - virology; Proteins; Receptors, G-Protein-Coupled - physiology; Recombination; Research and Analysis Methods; Signal transduction; Signal Transduction - physiology; Signaling; Stop codon; Supervision; Takeda, Shinji; Transfection; Viral infections; Virology; Viruses; Japan

Cytomegaloviruses (CMVs) encode cellular homologs to evade host immune functions. In this study, we analyzed the roles of GP33, a guinea pig CMV (GPCMV)-encoded G protein-coupled receptor (GPCR) homolog, in cellular signaling, viral growth and pathogenesis. The cDNA structure of GP33 was determined...