Systematic underestimation of the epigenetic clock and age acceleration in older subjects

• Published in: Genome Biology Vol. 20; no. 1; p. 283
• Main Authors: El Khoury, Louis Y., Gorrie-Stone, Tyler, Smart, Melissa, Hughes, Amanda, Bao, Yanchun, Andrayas, Alexandria, Burrage, Joe, Hannon, Eilis, Kumari, Meena, Mill, Jonathan, Schalkwyk, Leonard C.
• Format: Journal Article
• Language: English
• Published: England BioMed Central 17.12.2019; BMC
• Subjects: Age; Age acceleration; Aging - genetics; Biological Clocks; Blood; Cerebellum; CpG islands; data collection; Datasets; Deoxyribonucleic acid; DNA; DNA methylation; Epigenesis, Genetic; Epigenetic clock; Epigenetics; Genetic testing; genome; Humans; people; DNA methylation; Age acceleration; Epigenetic clock

The Horvath epigenetic clock is widely used. It predicts age quite well from 353 CpG sites in the DNA methylation profile in unknown samples and has been used to calculate "age acceleration" in various tissues and environments. The model systematically underestimates age in tissues from ol...