Toxoplasma gondii virulence factor ROP1 reduces parasite susceptibility to murine and human innate immune restriction

• Published in: PLoS pathogens Vol. 18; no. 12; p. e1011021
• Main Authors: Butterworth, Simon, Torelli, Francesca, Lockyer, Eloise J., Wagener, Jeanette, Song, Ok-Ryul, Broncel, Malgorzata, Russell, Matt R. G., Moreira-Souza, Aline Cristina A., Young, Joanna C., Treeck, Moritz
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 07.12.2022; Public Library of Science (PLoS)
• Subjects: Animals; Biology and Life Sciences; Carrier Proteins; CRISPR; Development and progression; Genes; Genomes; Genotype & phenotype; Health aspects; Humans; Immunity, Innate; Infections; Innate immunity; Macrophages; Medicine and Health Sciences; Mice; Mitochondrial Proteins - metabolism; Morbidity; Morphology; Parasite resistance; Parasites; Physiological aspects; Plasmids; Proteins; Protozoan Proteins - metabolism; Research and Analysis Methods; Rhoptry protein; Toxoplasma; Toxoplasma gondii; Toxoplasmosis; Virulence; Virulence (Microbiology); Virulence Factors; United Kingdom

Toxoplasma gondii is an intracellular parasite that can infect many host species and is a cause of significant human morbidity worldwide. T . gondii secretes a diverse array of effector proteins into the host cell which are critical for infection. The vast majority of these secreted proteins have no...