Role of macrophages in peripheral nerve injury and repair
Resident and inflammatory macrophages are essential effectors of the innate immune system. These cells provide innate immune defenses and regulate tissue and organ homeostasis. In addition to their roles in diseases such as cancer, obesity and osteoarthritis, they play vital roles in tissue repair a...
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| Abstract | Resident and inflammatory macrophages are essential effectors of the innate immune system. These cells provide innate immune defenses and regulate tissue and organ homeostasis. In addition to their roles in diseases such as cancer, obesity and osteoarthritis, they play vital roles in tissue repair and disease rehabilitation. Macrophages and other inflammatory cells are recruited to tissue injury sites where they promote changes in the microenvironment. Among the inflammatory cell types, only macrophages have both pro-inflammatory (M1) and anti-inflammatory (M2) actions, and M2 macrophages have four subtypes. The co-action of M1 and M2 subtypes can create a favorable microenvironment, releasing cytokines for damaged tissue repair. In this review, we discuss the activation of macrophages and their roles in severe peripheral nerve injury. We also describe the therapeutic potential of macrophages in nerve tissue engineering treatment and highlight approaches for enhancing M2 cell-mediated nerve repair and regeneration. |
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| AbstractList | Resident and inflammatory macrophages are essential effectors of the innate immune system. These cells provide innate immune defenses and regulate tissue and organ homeostasis. In addition to their roles in diseases such as cancer, obesity and osteoarthritis, they play vital roles in tissue repair and disease rehabilitation. Macrophages and other inflammatory cells are recruited to tissue injury sites where they promote changes in the microenvironment. Among the inflammatory cell types, only macrophages have both pro-inflammatory (M1) and anti-inflammatory (M2) actions, and M2 macrophages have four subtypes. The co-action of M1 and M2 subtypes can create a favorable microenvironment, releasing cytokines for damaged tissue repair. In this review, we discuss the activation of macrophages and their roles in severe peripheral nerve injury. We also describe the therapeutic potential of macrophages in nerve tissue engineering treatment and highlight approaches for enhancing M2 cell-mediated nerve repair and regeneration. Resident and inflammatory macrophages are essential effectors of the innate immune system. These cells provide innate immune defenses and regulate tissue and organ homeostasis. In addition to their roles in diseases such as cancer, obesity and osteoarthritis, they play vital roles in tissue repair and disease rehabilitation. Macrophages and other inflammatory cells are recruited to tissue injury sites where they promote changes in the microenvironment. Among the inflammatory cell types, only macrophages have both pro-inflammatory (M1) and anti-inflammatory (M2) actions, and M2 macrophages have four subtypes. The co-action of M1 and M2 subtypes can create a favorable microenvironment, releasing cytokines for damaged tissue repair. In this review, we discuss the activation of macrophages and their roles in severe peripheral nerve injury. We also describe the therapeutic potential of macrophages in nerve tissue engineering treatment and highlight approaches for enhancing M2 cell-mediated nerve repair and regeneration.Resident and inflammatory macrophages are essential effectors of the innate immune system. These cells provide innate immune defenses and regulate tissue and organ homeostasis. In addition to their roles in diseases such as cancer, obesity and osteoarthritis, they play vital roles in tissue repair and disease rehabilitation. Macrophages and other inflammatory cells are recruited to tissue injury sites where they promote changes in the microenvironment. Among the inflammatory cell types, only macrophages have both pro-inflammatory (M1) and anti-inflammatory (M2) actions, and M2 macrophages have four subtypes. The co-action of M1 and M2 subtypes can create a favorable microenvironment, releasing cytokines for damaged tissue repair. In this review, we discuss the activation of macrophages and their roles in severe peripheral nerve injury. We also describe the therapeutic potential of macrophages in nerve tissue engineering treatment and highlight approaches for enhancing M2 cell-mediated nerve repair and regeneration. Resident and inflammatory macrophages are essential effectors of the innate immune system.These cells provide innate immune defenses and regulate tissue and organ homeostasis.In addition to their roles in diseases such as cancer,obesity and osteoarthritis,they play vital roles in tissue repair and disease rehabil itation.Macrophages and other inflammatory cells are recruited to tissue injury sites where they promote changes in the microenvironment.Among the inflammatory cell types,only macrophages have both pro-inflammatory (M1) and anti-inflammatory (M2) actions,and M2 macrophages have four subtypes.The co-action of M1 and M2 subtypes can create a favorable microenvironment,releasing cytokines for damaged tissue repair.In this review,we discuss the activation of macrophages and their roles in severe peripheral nerve injury.We also describe the therapeutic potential of macrophages in nerve tissue engineering treatment and highlight approaches for enhancing M2 cell-mediated nerve repair and regeneration. |
| Audience | Academic |
| Author | Wang, Yu Han, Gong-Hai Gao, Gang Ding, Xiao Wei, Shuai Peng, Jiang Chang, Feng Liu, Ping Huang, Kun |
| AuthorAffiliation | Shanxi Medical University, Taiyuan, Shanxi Province, China;Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China%Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China%Kunming Medical University, Kunming, Yunnan Province, China%Shihezi University Medical College, Shihezi, Xinjiang Uygur Autonomous Region, China%Department of Orthopaedic Surgery, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, China%Anhui Medical University Air Force Clinical College, Hefei, Anhui Province, China |
| AuthorAffiliation_xml | – name: Shanxi Medical University, Taiyuan, Shanxi Province, China;Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China%Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China%Kunming Medical University, Kunming, Yunnan Province, China%Shihezi University Medical College, Shihezi, Xinjiang Uygur Autonomous Region, China%Department of Orthopaedic Surgery, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, China%Anhui Medical University Air Force Clinical College, Hefei, Anhui Province, China – name: 5 Department of Orthopaedic Surgery, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, China – name: 2 Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China – name: 6 Anhui Medical University Air Force Clinical College, Hefei, Anhui Province, China – name: 1 Shanxi Medical University, Taiyuan, Shanxi Province, China – name: 3 Kunming Medical University, Kunming, Yunnan Province, China – name: 4 Shihezi University Medical College, Shihezi, Xinjiang Uygur Autonomous Region, China |
| Author_xml | – sequence: 1 givenname: Ping surname: Liu fullname: Liu, Ping organization: Shanxi Medical University, Taiyuan, Shanxi Province; Institute of Orthopedics, Chinese PLA General Hospital, Beijing – sequence: 2 givenname: Jiang surname: Peng fullname: Peng, Jiang organization: Institute of Orthopedics, Chinese PLA General Hospital, Beijing – sequence: 3 givenname: Gong-Hai surname: Han fullname: Han, Gong-Hai organization: Kunming Medical University, Kunming, Yunnan Province – sequence: 4 givenname: Xiao surname: Ding fullname: Ding, Xiao organization: Shihezi University Medical College, Shihezi, Xinjiang Uygur Autonomous Region – sequence: 5 givenname: Shuai surname: Wei fullname: Wei, Shuai organization: Shihezi University Medical College, Shihezi, Xinjiang Uygur Autonomous Region – sequence: 6 givenname: Gang surname: Gao fullname: Gao, Gang organization: Department of Orthopaedic Surgery, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, Shanxi Province – sequence: 7 givenname: Kun surname: Huang fullname: Huang, Kun organization: Anhui Medical University Air Force Clinical College, Hefei, Anhui Province – sequence: 8 givenname: Feng surname: Chang fullname: Chang, Feng organization: Department of Orthopaedic Surgery, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, Shanxi Province – sequence: 9 givenname: Yu surname: Wang fullname: Wang, Yu organization: Institute of Orthopedics, Chinese PLA General Hospital, Beijing |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30964051$$D View this record in MEDLINE/PubMed |
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| Issue | 8 |
| Keywords | tissue engineering neural regeneration function nerve injury origin macrophage nerve regeneration nerve repair polarization |
| Language | English |
| License | http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Author contributions: Literature search: PL; paper writing: JP, YW, FC; paper revision: GHH, XD, SW, GG, KH. All authors approved the final version of the paper. |
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| OpenAccessLink | http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=8;spage=1335;epage=1342;aulast=Liu;type=0 |
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| PublicationPlace | India |
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| PublicationTitle | Neural regeneration research |
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| PublicationYear | 2019 |
| Publisher | Wolters Kluwer India Pvt. Ltd Medknow Publications and Media Pvt. Ltd Medknow Publications & Media Pvt. Ltd Shanxi Medical University, Taiyuan, Shanxi Province, China Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China%Institute of Orthopedics, Chinese PLA General Hospital, Beijing, China%Kunming Medical University, Kunming, Yunnan Province, China%Shihezi University Medical College, Shihezi, Xinjiang Uygur Autonomous Region, China%Department of Orthopaedic Surgery, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, China%Anhui Medical University Air Force Clinical College, Hefei, Anhui Province, China Wolters Kluwer - Medknow Wolters Kluwer Medknow Publications |
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| Snippet | Resident and inflammatory macrophages are essential effectors of the innate immune system. These cells provide innate immune defenses and regulate tissue and... Resident and inflammatory macrophages are essential effectors of the innate immune system.These cells provide innate immune defenses and regulate tissue and... |
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| SubjectTerms | Angiogenesis Anti-inflammatory agents Care and treatment Cell growth Chemokines Cytokines Disease Extracellular matrix Genotype & phenotype Homeostasis Immune system Inflammation Insulin-like growth factors Ligands Macrophages nerve regeneration; macrophage; origin; polarization; function; nerve injury; nerve repair; tissue engineering; neural regeneration Nervous system Nitric oxide Obesity Osteoarthritis Peripheral nervous system diseases Recruitment Review Tissue engineering Tumor necrosis factor-TNF Vascular endothelial growth factor Wound healing |
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| Title | Role of macrophages in peripheral nerve injury and repair |
| URI | http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=8;spage=1335;epage=1342;aulast=Liu;type=0 https://www.ncbi.nlm.nih.gov/pubmed/30964051 https://www.proquest.com/docview/2382126775 https://www.proquest.com/docview/2206223329 https://d.wanfangdata.com.cn/periodical/zgsjzsyj-e201908008 https://pubmed.ncbi.nlm.nih.gov/PMC6524518 https://doaj.org/article/43b42fb1c9d14a0689c4c5e4fff33d12 |
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