A short-term intervention trial with selenate, selenium-enriched yeast and selenium-enriched milk: effects on oxidative defence regulation

• Published in: British journal of nutrition Vol. 99; no. 4; pp. 883 - 892
• Main Authors: Ravn-Haren, Gitte, Bügel, Susanne, Krath, Britta N., Hoac, Tien, Stagsted, Jan, Jørgensen, Karina, Bresson, June R., Larsen, Erik H., Dragsted, Lars O.
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.04.2008
• Subjects: administration & dosage; Adolescent; Adult; adults; analysis; Animals; antioxidant activity; Antioxidants; Antioxidants - administration & dosage; Antioxidants - analysis; Base Sequence; Bioavailability; Biological and medical sciences; Biomarkers; Biomarkers - blood; Blood; blood chemistry; Blood lipids; blood platelets; C-Reactive Protein; C-Reactive Protein - analysis; Cancer; Cholesterol; Cholesterol - blood; Cholesterol, HDL; Cholesterol, HDL - blood; Cholesterol, LDL; Cholesterol, LDL - blood; Colleges & universities; Cross-Over Studies; Dairy products; Detoxification; Diet; dietary mineral supplements; dietary minerals; Dietary Supplements; DNA Primers; DNA Primers - genetics; Double-Blind Method; drug effects; Electrophile response elements; enriched foods; Erythrocytes; Feeding. Feeding behavior; Food, Fortified; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression - drug effects; genetics; Glutathione peroxidase; glutathione reductase (NADPH); glutathione transferase; glutathione-disulfide reductase; Health risks; Health Sciences; high density lipoprotein; Humans; Hälsovetenskap; leukocytes; Leukocytes - metabolism; lipid peroxidation; Lipids; Lipids - blood; low density lipoprotein; Male; Medical and Health Sciences; Medicin och hälsovetenskap; men; metabolism; Milk; Molecular Sequence Data; Nutrition and Dietetics; Nutrition research; nutritional intervention; Näringslära; Näringslära och dietkunskap; oxidation; Oxidation-Reduction; Oxidative defence; Plasma; protein synthesis; Reverse Transcriptase Polymerase Chain Reaction; Risk factors; Risk reduction; selenates; Selenium; Selenium - administration & dosage; Selenium - blood; Studies; thrombocytes; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Yeast, Dried; Yeasts; Glutathione peroxidase; Oxidative defence; Selenium; Blood lipids; Electrophile response elements; Short term; Yeast; Enzyme; Lipids; Response element; Blood; Vertebrata; Regulation(control); Mammalia; Peroxidases; Selenium: Oxidative defence: Electrophile response elements: Glutathione peroxidase: Blood lipids; Oxidoreductases; Milk

Increased Se intakes have been associated with decreased risk of cancer and CVD. Several mechanisms have been proposed, including antioxidant effects through selenoproteins, induction of carcinogen metabolism and effects on the blood lipid profile. In a 4 × 1 week randomised, double-blind cross-over...