In eubacteria, unlike eukaryotes, there is no evidence for selection favouring fail-safe 3' additional stop codons

• Published in: PLoS genetics Vol. 15; no. 9; p. e1008386
• Main Authors: Ho, Alexander T, Hurst, Laurence D
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 17.09.2019; Public Library of Science (PLoS)
• Subjects: 3' Untranslated Regions - genetics; Bacteria; Bacteria - genetics; Biochemistry; Biology and Life Sciences; Codon, Nonsense - genetics; Codon, Terminator - genetics; Codons; Costs; E coli; Eukaryota - genetics; Evolution; Evolution, Molecular; Gene expression; Gene Expression - genetics; Genes; Genome; Genomes; Genomics; Hypotheses; Informatics; Mutation; Nonsense Mediated mRNA Decay - genetics; Observations; Open Reading Frames - genetics; Physiological aspects; Prokaryotes; Proteins; Studies; United Kingdom; United Kingdom > UK

Errors throughout gene expression are likely deleterious, hence genomes are under selection to ameliorate their consequences. Additional stop codons (ASCs) are in-frame nonsense 'codons' downstream of the primary stop which may be read by translational machinery should the primary stop hav...