Senescent Fibroblasts Enhance Early Skin Carcinogenic Events via a Paracrine MMP-PAR-1 Axis - Malaquin, Nicolas; Vercamer, Chantal; Bouali, Fatima; Martien, Sébastien; Deruy, Emeric; Wernert, Nicolas; Chwastyniak, Maggy; Pinet, Florence; Abbadie, Corinne; Pourtier, Albin (PloS one, 2013)
Keywords: Adult; Age; Aging; Analysis; Antibodies; Biology; Blocking antibodies; Breast cancer; Carcinogenesis; Carcinogens; Cell migration; Cell Movement - drug effects; Cell Transformation, Neoplastic - genetics; Cell Transformation, Neoplastic - metabolism; Cells, Cultured; Cellular Senescence; Compartments; Conditioning; Epithelial-Mesenchymal Transition - genetics; Female; Fibroblasts; Fibroblasts - metabolism; Gelatinase A; Gene Expression; Hepatocyte Growth Factor - pharmacology; Humans; Inflammation; Interstitial collagenase; Keratinocytes; Keratinocytes - metabolism; Life Sciences; Matrix metalloproteinase; Matrix Metalloproteinase 1 - biosynthesis; Matrix Metalloproteinase 2 - biosynthesis; Matrix metalloproteinases; Matrix Metalloproteinases - genetics; Matrix Metalloproteinases - metabolism; Medicine; Melanoma; Mesenchyme; Metastases; Metastasis; Molecular modelling; Paracrine Communication; Paracrine signalling; Pharmacology; Proteinase-activated receptor 1; Receptor, PAR-1 - genetics; Receptor, PAR-1 - metabolism; Secretion; Secretome; Senescence; siRNA; Skin; Skin - metabolism; Skin - pathology; Skin carcinoma; Transformation; Transformed cells; Transforming Growth Factor beta1 - pharmacology; Tumors; Young Adult; France