Cross-Neutralizing Antibodies to Pandemic 2009 H1N1 and Recent Seasonal H1N1 Influenza A Strains Influenced by a Mutation in Hemagglutinin Subunit 2

• Published in: PLoS pathogens Vol. 7; no. 6; p. e1002081
• Main Authors: Wang, Wei, Anderson, Christine M., De Feo, Christopher J., Zhuang, Min, Yang, Hong, Vassell, Russell, Xie, Hang, Ye, Zhiping, Scott, Dorothy, Weiss, Carol D.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.06.2011; Public Library of Science (PLoS)
• Subjects: Antibodies, Neutralizing; Biology; Cell Line; Cross Reactions - immunology; Gene mutations; Genetic aspects; Health aspects; Hemagglutinins - genetics; Humans; Immunization; Influenza A Virus, H1N1 Subtype - classification; Influenza A Virus, H1N1 Subtype - immunology; Influenza vaccines; Influenza Vaccines - immunology; Medicine; Mutation; Neutralization; Pandemics; Point Mutation; Protein Subunits - genetics; Seasons; Swine flu; Swine influenza; Vaccination; Vaccines; Viruses; United States; Solomon Islands

Pandemic 2009 H1N1 influenza A virus (2009 H1N1) differs from H1N1 strains that circulated in the past 50 years, but resembles the A/New Jersey/1976 H1N1 strain used in the 1976 swine influenza vaccine. We investigated whether sera from persons immunized with the 1976 swine influenza or recent seaso...