Genome-wide analysis reveals no evidence of trans chromosomal regulation of mammalian immune development

• Published in: PLoS genetics Vol. 14; no. 6; p. e1007431
• Main Authors: Johanson, Timothy M, Coughlan, Hannah D, Lun, Aaron T L, Bediaga, Naiara G, Naselli, Gaetano, Garnham, Alexandra L, Harrison, Leonard C, Smyth, Gordon K, Allan, Rhys S
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.06.2018; Public Library of Science (PLoS)
• Subjects: Animals; Bioinformatics; Biology; Biology and Life Sciences; Cell cycle; Cell fate; Centromeres; Chromatin - chemistry; Chromatin - genetics; Chromatin - metabolism; Chromosomes; Chromosomes, Mammalian - chemistry; Chromosomes, Mammalian - genetics; Chromosomes, Mammalian - metabolism; Conformation; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA - genetics; DNA - metabolism; Flow Cytometry; Funding; Gene expression; Gene Expression Regulation; Genetic aspects; Genetic regulation; Genetic research; Genome; Genome-wide association studies; Genomes; Humans; Immune system; Immunity, Cellular - genetics; Immunoglobulins; Lymphocytes; Male; Mammals; Mammals - physiology; Medical research; Medicine and Health Sciences; Mice; Mice, Inbred C57BL; Nucleic Acid Conformation; Software; Stereoisomerism; Supervision; Telomeres; Zoological research; Australia

It has been proposed that interactions between mammalian chromosomes, or transchromosomal interactions (also known as kissing chromosomes), regulate gene expression and cell fate determination. Here we aimed to identify novel transchromosomal interactions in immune cells by high-resolution genome-wi...