Microevolution of Highly Pathogenic Avian Influenza A(H5N1) Viruses Isolated from Humans, Egypt, 2007–2011

• Published in: Emerging infectious diseases Vol. 19; no. 1; pp. 43 - 50
• Main Authors: Younan, Mary, Poh, Mee Kian, Elassal, Emad, Davis, Todd, Rivailler, Pierre, Balish, Amanda L., Simpson, Natosha, Jones, Joyce, Deyde, Varough, Loughlin, Rosette, Perry, Ije, Gubareva, Larisa, ElBadry, Maha A., Truelove, Shaun, Gaynor, Anne M., Mohareb, Emad, Amin, Magdy, Cornelius, Claire, Pimentel, Guillermo, Earhart, Kenneth, Naguib, Amel, Abdelghani, Ahmed S., Refaey, Samir, Klimov, Alexander I., Donis, Ruben O., Kandeel, Amr
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.01.2013; Centers for Disease Control and Prevention
• Subjects: Animals; Antigens, Viral - immunology; Avian influenza; Avian influenza viruses; Causes of; Chickens - virology; Disease transmission; Egypt; Egypt - epidemiology; Enzyme Assays; evolution; Evolution, Molecular; Genes, Viral; Genetic Drift; genomics; H5N1 avian influenza virus; Health aspects; Hemagglutinin Glycoproteins, Influenza Virus - classification; Hemagglutinin Glycoproteins, Influenza Virus - genetics; highly pathogenic; Humans; Influenza A Virus, H5N1 Subtype - classification; Influenza A Virus, H5N1 Subtype - genetics; Influenza A Virus, H5N1 Subtype - immunology; Influenza A Virus, H5N1 Subtype - pathogenicity; Influenza, Human - epidemiology; Influenza, Human - virology; Neuraminidase - genetics; Phylogeny; poultry; Poultry Diseases - epidemiology; Poultry Diseases - virology; Prevalence studies (Epidemiology); Egypt; United States

We analyzed highly pathogenic avian influenza A(H5N1) viruses isolated from humans infected in Egypt during 2007-2011. All analyzed viruses evolved from the lineage of subtype H5N1 viruses introduced into Egypt in 2006; we found minimal evidence of reassortment and no exotic introductions. The hemag...