Paternal genetic variants and risk of obstructive heart defects: A parent-of-origin approach

• Published in: PLoS genetics Vol. 17; no. 3; p. e1009413
• Main Authors: Patel, Jenil, Bircan, Emine, Tang, Xinyu, Orloff, Mohammed, Hobbs, Charlotte A., Browne, Marilyn L., Botto, Lorenzo D., Finnell, Richard H., Jenkins, Mary M., Olshan, Andrew, Romitti, Paul A., Shaw, Gary M., Werler, Martha M., Li, Jingyun, Nembhard, Wendy N.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 08.03.2021; Public Library of Science (PLoS)
• Subjects: Adult; Age; Alleles; Analysis; Aorta; Biology and Life Sciences; Birth defects; Cardiomyopathy, Hypertrophic, Familial - genetics; Chromosome Mapping; Congenital defects; Congenital heart disease; Deoxyribonucleic acid; Diabetes; DNA; Epigenetic inheritance; Epigenetics; Etiology; Families & family life; Female; Folic acid; Genes; Genetic aspects; Genetic diversity; Genetic Predisposition to Disease; Genetic Variation; Genotype; Glutathione; Heart; Heart Defects, Congenital - epidemiology; Heart Defects, Congenital - genetics; Heart Defects, Congenital - metabolism; Homocysteine; Humans; Infants; Inheritance Patterns; Male; Medicine and Health Sciences; Middle Aged; Mothers; Odds Ratio; Paternity testing; People and Places; Phenotype; Polymorphism, Single Nucleotide; Pregnancy; Prevention; Risk Assessment; Risk factors; Single-nucleotide polymorphism; Smoking; Statistical analysis; Stenosis; Vitamin B; Young Adult; United States; United States > US

Previous research on risk factors for obstructive heart defects (OHDs) focused on maternal and infant genetic variants, prenatal environmental exposures, and their potential interaction effects. Less is known about the role of paternal genetic variants or environmental exposures and risk of OHDs. We...