Estimating variance components in population scale family trees

• Published in: PLoS genetics Vol. 15; no. 5; p. e1008124
• Main Authors: Shor, Tal, Kalka, Iris, Geiger, Dan, Erlich, Yaniv, Weissbrod, Omer
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 09.05.2019; Public Library of Science (PLoS)
• Subjects: Animals; Biology and Life Sciences; Breeding of animals; Computer science; Computer Simulation; Decomposition; Digitization; Epidemiology; Family; Female; Genealogy; Genealogy and Heraldry; Genetic engineering; Genetic Fitness; Genetics, Population; Heritability; Humans; Linear Models; Longevity - genetics; Male; Medical records; Medical research; Medicine and Health Sciences; Methods; Models, Genetic; Pedigree; Physical Sciences; Plant breeding; Plants - genetics; Population; Quantitative genetics; Reproductive fitness; Research and Analysis Methods; Social Sciences; Software; Sparsity; Trees; New York; United States > US; Israel

The rapid digitization of genealogical and medical records enables the assembly of extremely large pedigree records spanning millions of individuals and trillions of pairs of relatives. Such pedigrees provide the opportunity to investigate the sociological and epidemiological history of human popula...