Integrative comparison of the genomic and transcriptomic landscape between prostate cancer patients of predominantly African or European genetic ancestry

• Published in: PLoS genetics Vol. 16; no. 2; p. e1008641
• Main Authors: Yuan, Jiao, Kensler, Kevin H., Hu, Zhongyi, Zhang, Youyou, Zhang, Tianli, Jiang, Junjie, Xu, Mu, Pan, Yutian, Long, Meixiao, Montone, Kathleen T., Tanyi, Janos L., Fan, Yi, Zhang, Rugang, Hu, Xiaowen, Rebbeck, Timothy R., Zhang, Lin
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 14.02.2020; Public Library of Science (PLoS)
• Subjects: 1-Phosphatidylinositol 3-kinase; Algorithms; Biology and Life Sciences; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Black or African American - genetics; Cancer genetics; Care and treatment; Chromatin Immunoprecipitation Sequencing; Cohort Studies; Comparative analysis; Computer applications; Epidemiology; Ethnicity; Gene expression; Gene Expression Regulation, Neoplastic; Genes; Genetic aspects; Genome, Human - genetics; Genomes; Genomics; Genotyping; Gynecology; Health aspects; Health Status Disparities; Hispanic Americans; Humans; Incidence; Male; Medicine and Health Sciences; Middle Aged; Minority & ethnic groups; Mortality; Mutation; Native Americans; Non-coding RNA; Nuclear Proteins - genetics; Obstetrics; Oncogene Proteins, Fusion - genetics; Oncology; Patients; Prevalence studies (Epidemiology); Prostate cancer; Prostatic Neoplasms - epidemiology; Prostatic Neoplasms - genetics; PTEN Phosphohydrolase - genetics; PTEN protein; Public health; Race; Racial differences; Receptors, Androgen - genetics; Repressor Proteins - genetics; Ribonucleic acid; RNA; RNA, Long Noncoding - metabolism; RNA-Seq; Signal transduction; Socioeconomic factors; Transcriptome - genetics; Transcriptomics; Tumors; White People - genetics; Ohio; United States > US; Massachusetts; Pennsylvania

Men of predominantly African Ancestry (AA) have higher prostate cancer (CaP) incidence and worse survival than men of predominantly European Ancestry (EA). While socioeconomic factors drive this disparity, genomic factors may also contribute to differences in the incidence and mortality rates. To co...