Virus-derived variation in diverse human genomes

• Published in: PLoS genetics Vol. 17; no. 4; p. e1009324
• Main Authors: Kojima, Shohei, Kamada, Anselmo Jiro, Parrish, Nicholas F.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 26.04.2021; Public Library of Science (PLoS)
• Subjects: Binding sites; Biology and Life Sciences; Blood cells; Chromosomes; Computer and Information Sciences; Datasets; Epstein-Barr virus; Gene expression; Genetic aspects; Genetic research; Genetic variation; Genomes; HIV; Homology; Host-virus relationships; Human genome; Human immunodeficiency virus; Leukocytes (mononuclear); Medicine and Health Sciences; Peripheral blood mononuclear cells; Reference materials; Research and Analysis Methods; tRNA; Vero cells; Viruses; Japan

Acquisition of genetic material from viruses by their hosts can generate inter-host structural genome variation. We developed computational tools enabling us to study virus-derived structural variants (SVs) in population-scale whole genome sequencing (WGS) datasets and applied them to 3,332 humans....