Autoreactive IgE Is Prevalent in Systemic Lupus Erythematosus and Is Associated with Increased Disease Activity and Nephritis

The presence of autoantibodies in systemic lupus erythematosus, particularly those of the IgG subclass, have long been associated with disease onset and activity. Here we explored the prevalence of autoreactive IgE in SLE and its relevance to disease in French (n = 79) and United States (US) (n = 11...

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Published inPloS one Vol. 9; no. 2; p. e90424
Main Authors Dema, Barbara, Pellefigues, Christophe, Hasni, Sarfaraz, Gault, Nathalie, Jiang, Chao, Ricks, Tiffany K., Bonelli, Michael M., Scheffel, Jörg, Sacré, Karim, Jablonski, Mathieu, Gobert, Delphine, Papo, Thomas, Daugas, Eric, Illei, Gabor, Charles, Nicolas, Rivera, Juan
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 28.02.2014
Public Library of Science (PLoS)
Subjects
Adult
Analysis
Anti-DNA antibodies
Antibodies
Antibodies, Antinuclear - blood
Antigens
Arthritis
Autoantibodies
Autoantigens
Autoantigens - blood
Autoimmune diseases
Autoimmunity
Biology
Chronic conditions
Cohort Studies
Disease
DNA - blood
DNA - immunology
Female
France
Humans
Immunoglobulin E
Immunoglobulin E - blood
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulins
Immunology
Internal medicine
Laboratories
Life Sciences
Lupus
Lupus Nephritis - blood
Lupus Nephritis - immunology
Lupus Nephritis - pathology
Male
Medicine
Middle Aged
Nephritis
Nephrology
Pathogenesis
Prediction models
Severity of Illness Index
Skin diseases
Systemic lupus erythematosus
United States
France
United States
United States > US
Maryland
Online AccessGet full text

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Abstract The presence of autoantibodies in systemic lupus erythematosus, particularly those of the IgG subclass, have long been associated with disease onset and activity. Here we explored the prevalence of autoreactive IgE in SLE and its relevance to disease in French (n = 79) and United States (US) (n = 117) cohorts with a mean age of 41.5 ± 12.7 and 43.6 ± 15.3 years and disease duration of 13.5 ± 8.5 and 16.6 ± 11.9 years, respectively. Our findings show that approximately 65% of all SLE subjects studied produced IgE antibodies to the seven autoantigens tested. This positivity was increased to almost 83% when only those subjects with active disease were considered. SLE subjects who were positive for anti-dsDNA, -Sm, and -SSB/La -specific IgE showed a highly significant association in the levels of these antibodies with disease activity similar to that of the corresponding IgG's. A strong association of IgE autoantibodies with active nephritis was also found in the combined cohort analysis. A test of the predictive value of autoreactive IgE's and IgGs for disease activity (SLE Disease Activity Index (SLEDAI) ≥ 4) revealed that the best predictors were dsDNA-specific IgE and IgG, and that the age of an SLE subject influenced this predictive model. The finding argue that the overall levels of IgE autoantibodies, independently or in combination with IgG autoantibodies, may serve as indicators of active disease.
AbstractList The presence of autoantibodies in systemic lupus erythematosus, particularly those of the IgG subclass, have long been associated with disease onset and activity. Here we explored the prevalence of autoreactive IgE in SLE and its relevance to disease in French (n = 79) and United States (US) (n = 117) cohorts with a mean age of 41.5±12.7 and 43.6±15.3 years and disease duration of 13.5±8.5 and 16.6±11.9 years, respectively. Our findings show that approximately 65% of all SLE subjects studied produced IgE antibodies to the seven autoantigens tested. This positivity was increased to almost 83% when only those subjects with active disease were considered. SLE subjects who were positive for anti-dsDNA, -Sm, and -SSB/La -specific IgE showed a highly significant association in the levels of these antibodies with disease activity similar to that of the corresponding IgG's. A strong association of IgE autoantibodies with active nephritis was also found in the combined cohort analysis. A test of the predictive value of autoreactive IgE’s and IgGs for disease activity (SLE Disease Activity Index (SLEDAI) ≥4) revealed that the best predictors were dsDNA-specific IgE and IgG, and that the age of an SLE subject influenced this predictive model. The finding argue that the overall levels of IgE autoantibodies, independently or in combination with IgG autoantibodies, may serve as indicators of active disease.
The presence of autoantibodies in systemic lupus erythematosus, particularly those of the IgG subclass, have long been associated with disease onset and activity. Here we explored the prevalence of autoreactive IgE in SLE and its relevance to disease in French (n = 79) and United States (US) (n = 117) cohorts with a mean age of 41.5±12.7 and 43.6±15.3 years and disease duration of 13.5±8.5 and 16.6±11.9 years, respectively. Our findings show that approximately 65% of all SLE subjects studied produced IgE antibodies to the seven autoantigens tested. This positivity was increased to almost 83% when only those subjects with active disease were considered. SLE subjects who were positive for anti-dsDNA, -Sm, and -SSB/La -specific IgE showed a highly significant association in the levels of these antibodies with disease activity similar to that of the corresponding IgG's. A strong association of IgE autoantibodies with active nephritis was also found in the combined cohort analysis. A test of the predictive value of autoreactive IgE's and IgGs for disease activity (SLE Disease Activity Index (SLEDAI) [greater than or equal to]4) revealed that the best predictors were dsDNA-specific IgE and IgG, and that the age of an SLE subject influenced this predictive model. The finding argue that the overall levels of IgE autoantibodies, independently or in combination with IgG autoantibodies, may serve as indicators of active disease.
The presence of autoantibodies in systemic lupus erythematosus, particularly those of the IgG subclass, have long been associated with disease onset and activity. Here we explored the prevalence of autoreactive IgE in SLE and its relevance to disease in French (n = 79) and United States (US) (n = 117) cohorts with a mean age of 41.5 ± 12.7 and 43.6 ± 15.3 years and disease duration of 13.5 ± 8.5 and 16.6 ± 11.9 years, respectively. Our findings show that approximately 65% of all SLE subjects studied produced IgE antibodies to the seven autoantigens tested. This positivity was increased to almost 83% when only those subjects with active disease were considered. SLE subjects who were positive for anti-dsDNA, -Sm, and -SSB/La -specific IgE showed a highly significant association in the levels of these antibodies with disease activity similar to that of the corresponding IgG's. A strong association of IgE autoantibodies with active nephritis was also found in the combined cohort analysis. A test of the predictive value of autoreactive IgE's and IgGs for disease activity (SLE Disease Activity Index (SLEDAI) ≥ 4) revealed that the best predictors were dsDNA-specific IgE and IgG, and that the age of an SLE subject influenced this predictive model. The finding argue that the overall levels of IgE autoantibodies, independently or in combination with IgG autoantibodies, may serve as indicators of active disease.
The presence of autoantibodies in systemic lupus erythematosus, particularly those of the IgG subclass, have long been associated with disease onset and activity. Here we explored the prevalence of autoreactive IgE in SLE and its relevance to disease in French (n = 79) and United States (US) (n = 117) cohorts with a mean age of 41.5 ± 12.7 and 43.6 ± 15.3 years and disease duration of 13.5 ± 8.5 and 16.6 ± 11.9 years, respectively. Our findings show that approximately 65% of all SLE subjects studied produced IgE antibodies to the seven autoantigens tested. This positivity was increased to almost 83% when only those subjects with active disease were considered. SLE subjects who were positive for anti-dsDNA, -Sm, and -SSB/La -specific IgE showed a highly significant association in the levels of these antibodies with disease activity similar to that of the corresponding IgG's. A strong association of IgE autoantibodies with active nephritis was also found in the combined cohort analysis. A test of the predictive value of autoreactive IgE's and IgGs for disease activity (SLE Disease Activity Index (SLEDAI) ≥ 4) revealed that the best predictors were dsDNA-specific IgE and IgG, and that the age of an SLE subject influenced this predictive model. The finding argue that the overall levels of IgE autoantibodies, independently or in combination with IgG autoantibodies, may serve as indicators of active disease.The presence of autoantibodies in systemic lupus erythematosus, particularly those of the IgG subclass, have long been associated with disease onset and activity. Here we explored the prevalence of autoreactive IgE in SLE and its relevance to disease in French (n = 79) and United States (US) (n = 117) cohorts with a mean age of 41.5 ± 12.7 and 43.6 ± 15.3 years and disease duration of 13.5 ± 8.5 and 16.6 ± 11.9 years, respectively. Our findings show that approximately 65% of all SLE subjects studied produced IgE antibodies to the seven autoantigens tested. This positivity was increased to almost 83% when only those subjects with active disease were considered. SLE subjects who were positive for anti-dsDNA, -Sm, and -SSB/La -specific IgE showed a highly significant association in the levels of these antibodies with disease activity similar to that of the corresponding IgG's. A strong association of IgE autoantibodies with active nephritis was also found in the combined cohort analysis. A test of the predictive value of autoreactive IgE's and IgGs for disease activity (SLE Disease Activity Index (SLEDAI) ≥ 4) revealed that the best predictors were dsDNA-specific IgE and IgG, and that the age of an SLE subject influenced this predictive model. The finding argue that the overall levels of IgE autoantibodies, independently or in combination with IgG autoantibodies, may serve as indicators of active disease.
Audience Academic
Author Jablonski, Mathieu
Charles, Nicolas
Jiang, Chao
Pellefigues, Christophe
Hasni, Sarfaraz
Rivera, Juan
Dema, Barbara
Sacré, Karim
Papo, Thomas
Bonelli, Michael M.
Gault, Nathalie
Daugas, Eric
Illei, Gabor
Gobert, Delphine
Ricks, Tiffany K.
Scheffel, Jörg
AuthorAffiliation 2 Institut National de la Santé et de la Recherche Médicale U699, Université Paris Diderot, Paris, France
7 Sjogren’s Syndrome Clinic, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America
5 Department of Nephrology, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Faculté de Médecine site Bichat, Paris, France
6 Clinical Research Unit, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Faculté de Médecine site Bichat, Paris, France
1 Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
4 Department of Internal Medicine, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Faculté de Médecine site Bichat, Paris, France
3 Office of the Clinical Director, National Institute of Arthritis and Muscul
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– name: 2 Institut National de la Santé et de la Recherche Médicale U699, Université Paris Diderot, Paris, France
– name: 8 Lymphocyte Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
– name: 1 Laboratory of Molecular Immunogenetics, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
– name: 3 Office of the Clinical Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
– name: INSERM-Université Paris-Sud, France
– name: 4 Department of Internal Medicine, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Faculté de Médecine site Bichat, Paris, France
– name: 5 Department of Nephrology, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Faculté de Médecine site Bichat, Paris, France
– name: 6 Clinical Research Unit, Hôpital Bichat, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Faculté de Médecine site Bichat, Paris, France
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  surname: Jiang
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  surname: Rivera
  fullname: Rivera, Juan
BackLink https://www.ncbi.nlm.nih.gov/pubmed/24587356$$D View this record in MEDLINE/PubMed
https://hal.science/hal-04897868$$DView record in HAL
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Cites_doi 10.1186/1476-7961-8-3
10.1007/s002960050059
10.4049/jimmunol.1002319
10.1191/0961203304lu485oa
10.3899/jrheum.100568
10.4049/jimmunol.138.9.2883
10.1371/journal.pone.0012280
10.1007/s002960050063
10.1002/art.1780251101
10.1191/0961203306lu2323oa
10.4049/jimmunol.139.10.3287
10.3109/08916934.2012.748751
10.1016/j.semarthrit.2012.05.001
10.1002/art.21379
10.1097/01.bor.0000135452.62800.8f
10.1056/NEJMra071297
10.1016/j.it.2004.03.005
10.1159/000288293
10.1159/000166485
10.1038/sj.ki.5002133
10.1038/nm.2159
10.1016/j.blre.2010.06.002
10.1002/art.1780400928
10.4049/jimmunol.1002648
10.1046/j.1365-2249.2002.01887.x
10.1056/NEJMoa021933
10.1371/journal.pone.0071458
10.1258/000456307780117993
10.1016/j.anai.2012.12.010
10.1093/rheumatology/41.1.62
10.1007/s11882-011-0216-5
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Copyright COPYRIGHT 2014 Public Library of Science
2014. This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Copyright_xml – notice: COPYRIGHT 2014 Public Library of Science
– notice: 2014. This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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DocumentTitleAlternate Autoreactive IgE Is Linked to Active Lupus
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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
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Competing Interests: The authors have declared that no competing interests exist.
Conceived and designed the experiments: BD NC SH ED GI JR. Performed the experiments: BD CP MMB JS CJ TKR. Analyzed the data: BD NG MMB SH GI NC JR. Contributed reagents/materials/analysis tools: SH KS MJ DG TP ED. Wrote the paper: BD SH NG MJ DG ED GI NC JR.
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References M Rodriguez Gomez (ref14) 2010; 185
M Frieri (ref1) 2013; 110
AM Miltenburg (ref20) 1993; 20
T Witte (ref21) 1998; 18
A Rahman (ref4) 2008; 358
H Permin (ref10) 1978; 86C
T Witte (ref25) 1998; 18
MP Madaio (ref30) 1987; 138
D Villalta (ref22) 2013; 8
MR Arbuckle (ref3) 2003; 349
NJ Sweiss (ref18) 2010; 5
AH Sawalha (ref2) 2004; 16
SN Tuma (ref33) 1981; 1
M Bijl (ref29) 2002; 41
AM Atta (ref11) 2010; 152
OG Pankewycz (ref31) 1987; 139
M Kalaaji (ref6) 2007; 71
AP Mantovani (ref24) 2010; 50
S Werwitzke (ref26) 2005; 52
N Charles (ref12) 2010; 16
AH Latiff (ref23) 2007; 44
J Altin (ref34) 2010; 24
K Schroeder (ref5) 2012; 46
X Bosch (ref13) 2011; 186
A Kenderov (ref28) 2002; 129
N Charles (ref32) 2011; 11
MB Pate (ref35) 2010; 8
B Livingston (ref17) 2012; 42
F Forger (ref27) 2004; 13
MC Hochberg (ref7) 1997; 40
T Mehrani (ref19) 2011; 38
EM Tan (ref15) 1982; 25
A Capron (ref8) 1977; 25
CG Kallenberg (ref16) 2006; 15
U Blank (ref9) 2004; 25
20512127 - Nat Med. 2010 Jun;16(6):701-7
9324032 - Arthritis Rheum. 1997 Sep;40(9):1725
11792881 - Rheumatology (Oxford). 2002 Jan;41(1):62-7
20178634 - Clin Mol Allergy. 2010 Feb 23;8:3
3553329 - J Immunol. 1987 May 1;138(9):2883-9
18305268 - N Engl J Med. 2008 Feb 28;358(9):929-39
327410 - Pathol Biol (Paris). 1977 May;25(5):287-90
16255055 - Arthritis Rheum. 2005 Nov;52(11):3629-38
16898172 - Lupus. 2006;15(7):397-402
23951169 - PLoS One. 2013;8(8):e71458
23181829 - Autoimmunity. 2013 Mar;46(2):121-7
23535084 - Ann Allergy Asthma Immunol. 2013 Apr;110(4):228-32
20952463 - J Rheumatol. 2011 Jan;38(1):64-8
15314490 - Curr Opin Rheumatol. 2004 Sep;16(5):534-40
20808864 - PLoS One. 2010;5(8):e12280
9782535 - Rheumatol Int. 1998;18(2):63-9
20197682 - Int Arch Allergy Immunol. 2010;152(4):401-6
17332738 - Kidney Int. 2007 Apr;71(7):664-72
3500215 - J Immunol. 1987 Nov 15;139(10):3287-94
309705 - Acta Pathol Microbiol Scand C. 1978 Oct;86C(5):245-9
21597041 - J Immunol. 2011 Jun 1;186(11):6083-90
9833247 - Rheumatol Int. 1998;18(3):85-91
21125163 - Rev Bras Reumatol. 2010 May-Jun;50(3):273-82
7348535 - Am J Nephrol. 1981;1(1):31-6
21068399 - J Immunol. 2010 Dec 15;185(12):7180-5
21805094 - Curr Allergy Asthma Rep. 2011 Oct;11(5):378-87
14870916 - Lupus. 2004;13(1):36-44
20637535 - Blood Rev. 2010 Jul-Sep;24(4-5):163-9
8441166 - J Rheumatol. 1993 Jan;20(1):53-8
14561795 - N Engl J Med. 2003 Oct 16;349(16):1526-33
15099567 - Trends Immunol. 2004 May;25(5):266-73
12100037 - Clin Exp Immunol. 2002 Jul;129(1):169-76
22704358 - Semin Arthritis Rheum. 2012 Dec;42(3):271-80
17362578 - Ann Clin Biochem. 2007 Mar;44(Pt 2):131-9
7138600 - Arthritis Rheum. 1982 Nov;25(11):1271-7
References_xml – volume: 86C
  start-page: 245
  year: 1978
  ident: ref10
  article-title: The prevalence of IgE antinuclear antibodies in rheumatoid arthritis and systemic lupus erythematosus
  publication-title: Acta Pathol Microbiol Scand C
– volume: 8
  start-page: 3
  year: 2010
  ident: ref35
  article-title: Regulation and dysregulation of immunoglobulin E: a molecular and clinical perspective
  publication-title: Clin Mol Allergy
  doi: 10.1186/1476-7961-8-3
– volume: 18
  start-page: 63
  year: 1998
  ident: ref21
  article-title: Association of IgA anti-dsDNA antibodies with vasculitis and disease activity in systemic lupus erythematosus. SLE Study Group
  publication-title: Rheumatol Int
  doi: 10.1007/s002960050059
– volume: 185
  start-page: 7180
  year: 2010
  ident: ref14
  article-title: Basophils support the survival of plasma cells in mice
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1002319
– volume: 13
  start-page: 36
  year: 2004
  ident: ref27
  article-title: Clinical significance of anti-dsDNA antibody isotypes: IgG/IgM ratio of anti-dsDNA antibodies as a prognostic marker for lupus nephritis
  publication-title: Lupus
  doi: 10.1191/0961203304lu485oa
– volume: 38
  start-page: 64
  year: 2011
  ident: ref19
  article-title: Association of IgA Anti-beta2 glycoprotein I with clinical and laboratory manifestations of systemic lupus erythematosus
  publication-title: J Rheumatol
  doi: 10.3899/jrheum.100568
– volume: 138
  start-page: 2883
  year: 1987
  ident: ref30
  article-title: Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits
  publication-title: J Immunol
  doi: 10.4049/jimmunol.138.9.2883
– volume: 5
  start-page: e12280
  year: 2010
  ident: ref18
  article-title: IgA anti-beta2-glycoprotein I autoantibodies are associated with an increased risk of thromboembolic events in patients with systemic lupus erythematosus
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0012280
– volume: 18
  start-page: 85
  year: 1998
  ident: ref25
  article-title: IgM anti-dsDNA antibodies in systemic lupus erythematosus: negative association with nephritis. SLE Study Group
  publication-title: Rheumatol Int
  doi: 10.1007/s002960050063
– volume: 25
  start-page: 1271
  year: 1982
  ident: ref15
  article-title: The 1982 revised criteria for the classification of systemic lupus erythematosus
  publication-title: Arthritis Rheum
  doi: 10.1002/art.1780251101
– volume: 50
  start-page: 273
  year: 2010
  ident: ref24
  article-title: Prevalence of IgA deficiency in adult systemic lupus erythematosus and the study of the association with its clinical and autoantibody profiles
  publication-title: Rev Bras Rheumatol
– volume: 15
  start-page: 397
  year: 2006
  ident: ref16
  article-title: Quantitation of autoantibodies in systemic autoimmune diseases: clinically useful?
  publication-title: Lupus
  doi: 10.1191/0961203306lu2323oa
– volume: 139
  start-page: 3287
  year: 1987
  ident: ref31
  article-title: Polyreactive autoantibodies are nephritogenic in murine lupus nephritis
  publication-title: J Immunol
  doi: 10.4049/jimmunol.139.10.3287
– volume: 46
  start-page: 121
  year: 2012
  ident: ref5
  article-title: The role of somatic hypermutation in the generation of pathogenic antibodies in SLE
  publication-title: Autoimmunity
  doi: 10.3109/08916934.2012.748751
– volume: 42
  start-page: 271
  year: 2012
  ident: ref17
  article-title: Differences in autoantibody profiles and disease activity and damage scores between childhood- and adult-onset systemic lupus erythematosus: a meta-analysis
  publication-title: Semin Arthritis Rheum
  doi: 10.1016/j.semarthrit.2012.05.001
– volume: 52
  start-page: 3629
  year: 2005
  ident: ref26
  article-title: Inhibition of lupus disease by anti-double-stranded DNA antibodies of the IgM isotype in the (NZB x NZW)F1 mouse
  publication-title: Arthritis Rheum
  doi: 10.1002/art.21379
– volume: 25
  start-page: 287
  year: 1977
  ident: ref8
  article-title: IgE and cells in protective immunity
  publication-title: Pathol Biol (Paris)
– volume: 16
  start-page: 534
  year: 2004
  ident: ref2
  article-title: Antinuclear autoantibodies in systemic lupus erythematosus
  publication-title: Curr Opin Rheumatol
  doi: 10.1097/01.bor.0000135452.62800.8f
– volume: 358
  start-page: 929
  year: 2008
  ident: ref4
  article-title: Systemic lupus erythematosus
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra071297
– volume: 25
  start-page: 266
  year: 2004
  ident: ref9
  article-title: The ins and outs of IgE-dependent mast-cell exocytosis
  publication-title: Trends Immunol
  doi: 10.1016/j.it.2004.03.005
– volume: 152
  start-page: 401
  year: 2010
  ident: ref11
  article-title: Autoimmune response of IgE antibodies to cellular self-antigens in systemic Lupus Erythematosus
  publication-title: Int Arch Allergy Immunol
  doi: 10.1159/000288293
– volume: 1
  start-page: 31
  year: 1981
  ident: ref33
  article-title: Glomerular IgE deposits in patients with lupus nephritis
  publication-title: Am J Nephrol
  doi: 10.1159/000166485
– volume: 71
  start-page: 664
  year: 2007
  ident: ref6
  article-title: Glomerular apoptotic nucleosomes are central target structures for nephritogenic antibodies in human SLE nephritis
  publication-title: Kidney Int
  doi: 10.1038/sj.ki.5002133
– volume: 20
  start-page: 53
  year: 1993
  ident: ref20
  article-title: IgA anti-dsDNA antibodies in systemic lupus erythematosus: occurrence, incidence and association with clinical and laboratory variables of disease activity
  publication-title: J Rheumatol
– volume: 16
  start-page: 701
  year: 2010
  ident: ref12
  article-title: Basophils and the T helper 2 environment can promote the development of lupus nephritis
  publication-title: Nat Med
  doi: 10.1038/nm.2159
– volume: 24
  start-page: 163
  year: 2010
  ident: ref34
  article-title: Understanding the genetic regulation of IgE production
  publication-title: Blood Rev
  doi: 10.1016/j.blre.2010.06.002
– volume: 40
  start-page: 1725
  year: 1997
  ident: ref7
  article-title: Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus
  publication-title: Arthritis Rheum
  doi: 10.1002/art.1780400928
– volume: 186
  start-page: 6083
  year: 2011
  ident: ref13
  article-title: Basophils, IgE, and autoantibody-mediated kidney disease
  publication-title: J Immunol
  doi: 10.4049/jimmunol.1002648
– volume: 129
  start-page: 169
  year: 2002
  ident: ref28
  article-title: Lupus-specific kidney deposits of HSP90 are associated with altered IgG idiotypic interactions of anti-HSP90 autoantibodies
  publication-title: Clin Exp Immunol
  doi: 10.1046/j.1365-2249.2002.01887.x
– volume: 349
  start-page: 1526
  year: 2003
  ident: ref3
  article-title: Development of autoantibodies before the clinical onset of systemic lupus erythematosus
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa021933
– volume: 8
  start-page: e71458
  year: 2013
  ident: ref22
  article-title: Anti-dsDNA antibody isotypes in systemic lupus erythematosus: IgA in addition to IgG anti-dsDNA help to identify glomerulonephritis and active disease
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0071458
– volume: 44
  start-page: 131
  year: 2007
  ident: ref23
  article-title: The clinical significance of immunoglobulin A deficiency
  publication-title: Ann Clin Biochem
  doi: 10.1258/000456307780117993
– volume: 110
  start-page: 228
  year: 2013
  ident: ref1
  article-title: Mechanisms of disease for the clinician: systemic lupus erythematosus
  publication-title: Ann Allergy Asthma Immunol
  doi: 10.1016/j.anai.2012.12.010
– volume: 41
  start-page: 62
  year: 2002
  ident: ref29
  article-title: IgG subclass distribution of autoantibodies differs between renal and extra-renal relapses in patients with systemic lupus erythematosus
  publication-title: Rheumatology (Oxford)
  doi: 10.1093/rheumatology/41.1.62
– volume: 11
  start-page: 378
  year: 2011
  ident: ref32
  article-title: Basophils and autoreactive IgE in the pathogenesis of systemic lupus erythematosus
  publication-title: Current allergy and asthma reports
  doi: 10.1007/s11882-011-0216-5
– reference: 15314490 - Curr Opin Rheumatol. 2004 Sep;16(5):534-40
– reference: 23951169 - PLoS One. 2013;8(8):e71458
– reference: 20512127 - Nat Med. 2010 Jun;16(6):701-7
– reference: 15099567 - Trends Immunol. 2004 May;25(5):266-73
– reference: 20952463 - J Rheumatol. 2011 Jan;38(1):64-8
– reference: 3553329 - J Immunol. 1987 May 1;138(9):2883-9
– reference: 7348535 - Am J Nephrol. 1981;1(1):31-6
– reference: 17362578 - Ann Clin Biochem. 2007 Mar;44(Pt 2):131-9
– reference: 309705 - Acta Pathol Microbiol Scand C. 1978 Oct;86C(5):245-9
– reference: 21805094 - Curr Allergy Asthma Rep. 2011 Oct;11(5):378-87
– reference: 21125163 - Rev Bras Reumatol. 2010 May-Jun;50(3):273-82
– reference: 20197682 - Int Arch Allergy Immunol. 2010;152(4):401-6
– reference: 7138600 - Arthritis Rheum. 1982 Nov;25(11):1271-7
– reference: 20637535 - Blood Rev. 2010 Jul-Sep;24(4-5):163-9
– reference: 8441166 - J Rheumatol. 1993 Jan;20(1):53-8
– reference: 14561795 - N Engl J Med. 2003 Oct 16;349(16):1526-33
– reference: 9782535 - Rheumatol Int. 1998;18(2):63-9
– reference: 21068399 - J Immunol. 2010 Dec 15;185(12):7180-5
– reference: 327410 - Pathol Biol (Paris). 1977 May;25(5):287-90
– reference: 22704358 - Semin Arthritis Rheum. 2012 Dec;42(3):271-80
– reference: 16898172 - Lupus. 2006;15(7):397-402
– reference: 20808864 - PLoS One. 2010;5(8):e12280
– reference: 16255055 - Arthritis Rheum. 2005 Nov;52(11):3629-38
– reference: 21597041 - J Immunol. 2011 Jun 1;186(11):6083-90
– reference: 23535084 - Ann Allergy Asthma Immunol. 2013 Apr;110(4):228-32
– reference: 9833247 - Rheumatol Int. 1998;18(3):85-91
– reference: 9324032 - Arthritis Rheum. 1997 Sep;40(9):1725
– reference: 12100037 - Clin Exp Immunol. 2002 Jul;129(1):169-76
– reference: 11792881 - Rheumatology (Oxford). 2002 Jan;41(1):62-7
– reference: 3500215 - J Immunol. 1987 Nov 15;139(10):3287-94
– reference: 14870916 - Lupus. 2004;13(1):36-44
– reference: 18305268 - N Engl J Med. 2008 Feb 28;358(9):929-39
– reference: 17332738 - Kidney Int. 2007 Apr;71(7):664-72
– reference: 23181829 - Autoimmunity. 2013 Mar;46(2):121-7
– reference: 20178634 - Clin Mol Allergy. 2010 Feb 23;8:3
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Snippet The presence of autoantibodies in systemic lupus erythematosus, particularly those of the IgG subclass, have long been associated with disease onset and...
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SubjectTerms Adult
Analysis
Anti-DNA antibodies
Antibodies
Antibodies, Antinuclear - blood
Antigens
Arthritis
Autoantibodies
Autoantigens
Autoantigens - blood
Autoimmune diseases
Autoimmunity
Biology
Chronic conditions
Cohort Studies
Disease
DNA - blood
DNA - immunology
Female
France
Humans
Immunoglobulin E
Immunoglobulin E - blood
Immunoglobulin G
Immunoglobulin G - blood
Immunoglobulins
Immunology
Internal medicine
Laboratories
Life Sciences
Lupus
Lupus Nephritis - blood
Lupus Nephritis - immunology
Lupus Nephritis - pathology
Male
Medicine
Middle Aged
Nephritis
Nephrology
Pathogenesis
Prediction models
Severity of Illness Index
Skin diseases
Systemic lupus erythematosus
United States
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Title Autoreactive IgE Is Prevalent in Systemic Lupus Erythematosus and Is Associated with Increased Disease Activity and Nephritis
URI https://www.ncbi.nlm.nih.gov/pubmed/24587356
https://www.proquest.com/docview/1503272224
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https://hal.science/hal-04897868
https://pubmed.ncbi.nlm.nih.gov/PMC3938730
https://doaj.org/article/9e6280a5db3f4d3b849c003ce6aa782c
http://dx.doi.org/10.1371/journal.pone.0090424
Volume 9
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