Circulating MiRNAs of ‘Asian Indian Phenotype’ Identified in Subjects with Impaired Glucose Tolerance and Patients with Type 2 Diabetes

• Published in: PloS one Vol. 10; no. 5; p. e0128372
• Main Authors: Prabu, Paramasivam, Rome, Sophie, Sathishkumar, Chandrakumar, Aravind, Sankaramoorthy, Mahalingam, Balakumar, Shanthirani, Coimbatore Subramanian, Gastebois, Caroline, Villard, Audrey, Mohan, Viswanathan, Balasubramanyam, Muthuswamy
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.05.2015; Public Library of Science (PLoS)
• Subjects: Adult; Animals; Asian people; Asians; Biomarkers; Biomarkers - blood; Blood Glucose - metabolism; Brain research; Cardiovascular diseases; Care and treatment; Case-Control Studies; Cholesterol; Cholesterol - blood; Development and progression; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental - blood; Diabetes Mellitus, Experimental - genetics; Diabetes Mellitus, Experimental - pathology; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - ethnology; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - pathology; Disease prevention; Education; Ethnic factors; Ethnic Groups; Etiology; Fasting; Female; Gene expression; Gene Expression Regulation; Genetic aspects; Glucose; Glucose Intolerance; Glucose tolerance; Glucose Tolerance Test; Glycated Hemoglobin A - metabolism; Hemoglobin; Homeostasis; Humans; Insulin; Insulin - blood; Insulin Resistance; Laboratories; Life Sciences; Male; Metabolism; Mice; Mice, Inbred C57BL; MicroRNA; MicroRNAs; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; Minority & ethnic groups; miRNA; Obesity; Patients; Phenotype; Population studies; Prediabetic state; Prediabetic State - blood; Prediabetic State - ethnology; Prediabetic State - genetics; Prediabetic State - pathology; Risk factors; Studies; Type 2 diabetes; India; Humans; Middle Aged; Insulin/blood; Male; Glucose Intolerance; Case-Control Studies; Prediabetic State/blood/ethnology/genetics/pathology; Ethnic Groups; Glycosylated/metabolism; Cholesterol/blood; Experimental/blood/genetics/pathology; Type 2/blood/ethnology/genetics/pathology; Female; Biomarkers/blood; Adult; Hemoglobin A; MicroRNAs/blood/genetics; Glucose Tolerance Test; Fasting; Blood Glucose/metabolism; Insulin Resistance; Gene Expression Regulation; Diabetes Mellitus; Inbred C57BL; Phenotype; Animals; Mice

Several omics technologies are underway worldwide with an aim to unravel the pathophysiology of a complex phenotype such as type 2 diabetes mellitus (T2DM). While recent studies imply a clinically relevant and potential biomarker role of circulatory miRNAs in the etiology of T2DM, there is lack of d...