Ratios of Four STAT3 Splice Variants in Human Eosinophils and Diffuse Large B Cell Lymphoma Cells

• Published in: PloS one Vol. 10; no. 5; p. e0127243
• Main Authors: Turton, Keren B., Annis, Douglas S., Rui, Lixin, Esnault, Stephane, Mosher, Deane F.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 18.05.2015; Public Library of Science (PLoS)
• Series: PLoS ONE
• Subjects: Alternative Splicing; Amino Acid Sequence; B-cell lymphoma; B-Lymphocytes - pathology; Base Sequence; Binding sites; Cell Line, Tumor; Cloning; Codons; Cytokines; Eosinophils; Eosinophils - metabolism; Genes; Genomics; Germinal Center - pathology; Human tissues; Humans; Inspection; Kinases; Leukemia; Leukocytes; Leukocytes (eosinophilic); Life Sciences; Lymphocytes B; Lymphoma; Lymphoma, Large B-Cell, Diffuse - genetics; Lymphomas; Molecular Sequence Data; Nucleotide sequence; Phosphorylation; Plasmids; Proteins; Proteomics; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Ribonucleic acid; RNA; RNA sequencing; RNA Splice Sites - genetics; RNA, Messenger - genetics; RNA, Messenger - metabolism; Rodents; Stat3 protein; STAT3 Transcription Factor - chemistry; STAT3 Transcription Factor - genetics; Tissues; Transcription; Transcription, Genetic; Lymphoma, Large B-Cell, Diffuse; Amino Acid Sequence; Reproducibility of Results; RNA Splice Sites; Alternative Splicing; Humans; B-Lymphocytes; Molecular Sequence Data; Germinal Center; Base Sequence; Cell Line, Tumor; Transcription, Genetic; STAT3 Transcription Factor; RNA, Messenger; Real-Time Polymerase Chain Reaction; Eosinophils

Signal transducer and activator of transcription 3 (STAT3) is a key mediator of leukocyte differentiation and proliferation. The 3' end of STAT3 transcripts is subject to two alternative splicing events. One results in either full-length STAT3α or in STAT3β, which lacks part of the C-terminal t...