HIV-1 Replication in the Central Nervous System Occurs in Two Distinct Cell Types

• Published in: PLoS pathogens Vol. 7; no. 10; p. e1002286
• Main Authors: Schnell, Gretja, Joseph, Sarah, Spudich, Serena, Price, Richard W., Swanstrom, Ronald
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.10.2011; Public Library of Science (PLoS)
• Subjects: Acquired immune deficiency syndrome; AIDS; AIDS Dementia Complex - cerebrospinal fluid; AIDS Dementia Complex - pathology; AIDS Dementia Complex - virology; Antiretroviral drugs; Biology; Blood; CD4 Antigens - biosynthesis; CD4 Antigens - blood; Cell Line; Central nervous system; Central Nervous System - virology; Cerebrospinal Fluid - cytology; Cerebrospinal Fluid - virology; Decay; Dementia; Dementia disorders; Drug therapy; Genetic Variation; Health aspects; HEK293 Cells; HIV; HIV (Viruses); HIV-1 - pathogenicity; HIV-1 - physiology; Human immunodeficiency virus; Humans; Leukocytosis; Lymphocytes; Macrophages - virology; Molecular Sequence Data; Physiological aspects; Population; Receptors, CCR5 - physiology; T cells; T-Lymphocytes - virology; Virus Replication; Viruses; United States; HIV-1; Cell Line; T-Lymphocytes; Antigens, CD4; Cerebrospinal Fluid; Humans; Molecular Sequence Data; Macrophages; AIDS Dementia Complex; Genetic Variation; Central Nervous System; Leukocytosis; Virus Replication; HEK293 Cells; Receptors, CCR5

Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system (CNS) can lead to the development of HIV-1-associated dementia (HAD). We examined the virological characteristics of HIV-1 in the cerebrospinal fluid (CSF) of HAD subjects to explore the association between independe...