Acute Undifferentiated Febrile Illness in Rural Cambodia: A 3-Year Prospective Observational Study

• Published in: PloS one Vol. 9; no. 4; p. e95868
• Main Authors: Mueller, Tara C., Siv, Sovannaroth, Khim, Nimol, Kim, Saorin, Fleischmann, Erna, Ariey, Frédéric, Buchy, Philippe, Guillard, Bertrand, González, Iveth J., Christophel, Eva-Maria, Abdur, Rashid, von Sonnenburg, Frank, Bell, David, Menard, Didier
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.04.2014; Public Library of Science (PLoS)
• Subjects: Acute Disease; Adolescent; Adult; Algorithms; Biology and Life Sciences; Blood; C-Reactive Protein; C-Reactive Protein - metabolism; Cambodia; Cambodia - epidemiology; Case management; Case-Control Studies; Child; Coinfection; Coinfection - blood; Coinfection - complications; Coinfection - epidemiology; Dengue; Dengue - blood; Dengue - complications; Dengue - epidemiology; Dengue fever; Diagnosis; Diagnostic systems; Distribution; Doxycycline; Drug therapy; Eardrum; Epidemiology; Female; Fever; Fever of Unknown Origin; Fever of Unknown Origin - blood; Fever of Unknown Origin - epidemiology; Fever of Unknown Origin - etiology; Guidelines; Health care facilities; Health surveillance; Human health and pathology; Humans; Illnesses; Infectious diseases; Influenza; Influenza, Human; Influenza, Human - blood; Influenza, Human - complications; Influenza, Human - epidemiology; Laboratories; Leptospirosis; Leptospirosis - blood; Leptospirosis - complications; Leptospirosis - epidemiology; Life Sciences; Malaria; Malaria - blood; Malaria - complications; Malaria - epidemiology; Male; Medicine and Health Sciences; Middle Aged; Observational studies; Parasites; Parasitology; Pathogens; Pharynx; Prevalence; Prospective Studies; Public health; Reagent Kits, Diagnostic; Research and Analysis Methods; Rural areas; Rural Population; Santé publique et épidémiologie; Transportation services; Tropical diseases; Vector-borne diseases; Viral diseases; Viruses; Young Adult; Cambodia; Laos; Plasmodium; Malaria; Fevers; Bacterial pathogens; Dengue virus; Malarial parasites; Viral pathogens; Leptospira
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0095868

In the past decade, malaria control has been successfully implemented in Cambodia, leading to a substantial decrease in reported cases. Wide-spread use of malaria rapid diagnostic tests (RDTs) has revealed a large burden of malaria-negative fever cases, for which no clinical management guidelines ex...