Absence of the Adaptor Protein PEA-15 Is Associated with Altered Pattern of Th Cytokines Production by Activated CD4+ T Lymphocytes In Vitro, and Defective Red Blood Cell Alloimmune Response In Vivo

• Published in: PloS one Vol. 10; no. 8; p. e0136885
• Main Authors: Kerbrat, Stéphane, Vingert, Benoit, Junier, Marie-Pierre, Castellano, Flavia, Renault-Mihara, François, Dos Reis Tavares, Silvina, Surenaud, Mathieu, Noizat-Pirenne, France, Boczkowski, Jorge, Guellaën, Georges, Chneiweiss, Hervé, Le Gouvello, Sabine
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 28.08.2015; Public Library of Science (PLoS)
• Subjects: Animals; Apoptosis; Blood; Blood Transfusion; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; Cell activation; Cell cycle; Cell division; Cyclin E; Cytokines; Cytokines - metabolism; Cytosol; Deoxyribonucleic acid; Disease Models, Animal; DNA; Erythrocytes; FADD protein; Flow cytometry; Genetic aspects; Helper cells; Human health and pathology; Immune response; Immune response (humoral); Immune response regulation; Immune system; Immunization, Passive; In Vitro Techniques; Interleukin 2; Interleukin 4; Isoimmunization; Kinases; L-selectin; Life Sciences; Lymphatic system; Lymphocyte Activation - immunology; Lymphocytes; Lymphocytes T; MAP Kinase Signaling System; Mice; Molecular chains; Neurosciences; Phosphoproteins - deficiency; Properties; Proteins; Receptors, Antigen, T-Cell - metabolism; Signaling; T cell receptors; T-cell receptor; T-Lymphocytes, Helper-Inducer - immunology; Transport proteins; γ-Interferon; France; United States > US; Germany

TCR-dependent and costimulation signaling, cell division, and cytokine environment are major factors driving cytokines expression induced by CD4(+) T cell activation. PEA-15 15 (Protein Enriched in Astrocyte / 15 kDa) is an adaptor protein that regulates death receptor-induced apoptosis and prolifer...