Genome-Wide Fine-Scale Recombination Rate Variation in Drosophila melanogaster

• Published in: PLoS genetics Vol. 8; no. 12; p. e1003090
• Main Authors: Chan, Andrew H., Jenkins, Paul A., Song, Yun S.
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.12.2012; Public Library of Science (PLoS)
• Subjects: Africa; Animal genetics; Animals; Base Composition; Biology; Chromosome Mapping; Chromosomes; Chromosomes - genetics; Crossing Over, Genetic; Drosophila; Drosophila melanogaster - genetics; Estimates; Evolution, Molecular; Experiments; Gene loci; Genetic aspects; Genetic engineering; Genetic recombination; Genetic Variation; Genome, Insect; Genomes; Genomics; Mathematics; Metagenomics; North America; Physiological aspects; Polymorphism, Single Nucleotide; Population; Recombination, Genetic; Scholarships & fellowships; Statistical methods; North America; Africa; United States
• ISSN: 1553-7404; 1553-7390; 1553-7404
• DOI: 10.1371/journal.pgen.1003090

Estimating fine-scale recombination maps of Drosophila from population genomic data is a challenging problem, in particular because of the high background recombination rate. In this paper, a new computational method is developed to address this challenge. Through an extensive simulation study, it i...